Plaa phospholipase A2, activating protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plaaprovided by RGD
Official Full Name: phospholipase A2, activating proteinprovided by RGD
Primary source: RGD:621245
See related: EnsemblRapid:ENSRNOG00000007753 AllianceGenome:RGD:621245
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Plap; PLA2P
Summary: Predicted to enable phospholipase A2 activator activity and ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of protein K63-linked ubiquitination; positive regulation of dendrite extension; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within inflammatory response. Predicted to be located in extracellular exosome and synapse. Predicted to be active in cytoplasm and nucleus. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 239.3), Heart (RPKM 232.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (114544327..114576023, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (109428600..109460373, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (113548913..113578928, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytosolic phospholipase A2 mRNA is expressed in rat injured spinal cord at 7 days after spinal cord injury.
Title: Cytosolic phospholipase A2 protein as a novel therapeutic target for spinal cord injury.
These data suggest that the ANG II-induced neointimal growth is mediated by the activation of Akt through a mechanism dependent on cPLA2 and PLD2 activation in balloon-injured rat carotid arteries.
Title: ANG II-induced neointimal growth is mediated via cPLA2- and PLD2-activated Akt in balloon-injured rat carotid artery.
PLAA is a specific activator of PLA2 in growth plate chondrocytes, suggesting that it mediates the membrane effect of 1alpha,25(OH)2D3, thereby modulating physiological response.
Title: Phospholipase A2 activating protein (PLAA) is required for 1alpha,25(OH)2D3 signaling in growth plate chondrocytes.

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General gene information

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Markers

RH136469 (e-PCR)
- UniSTS:210454

AA850736 (e-PCR)
- UniSTS:250444

AW208417 (e-PCR)
- UniSTS:179030

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phospholipase A2 activator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	ISO Inferred from Sequence Orthology more info
involved_in macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dendrite extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase A2 activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic vesicle recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic vesicle recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phospholipase A-2-activating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053866.3 → NP_446318.3 phospholipase A-2-activating protein

See identical proteins and their annotated locations for NP_446318.3

Status: VALIDATED

Source sequence(s)

BP498567, CB701630, CF110238, CK366206, CV109083, CV110320

UniProtKB/Swiss-Prot

P54319

UniProtKB/TrEMBL

A6JRG3, A6JRG5

Conserved Domains (4) summary

cd00200
Location:10 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:69 → 110

7WD40; WD40 repeat [structural motif]

pfam08324
Location:536 → 789

PUL; PUL domain

pfam09070
Location:346 → 459

PFU; PFU (PLAA family ubiquitin binding)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

114544327..114576023 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109151.2 → XP_038965079.1 phospholipase A-2-activating protein isoform X1

UniProtKB/TrEMBL

A0A8I6A2M3, A6JRG3, A6JRG4

Related

ENSRNOP00000085067.1, ENSRNOT00000094582.2

Conserved Domains (4) summary

cd00200
Location:10 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:69 → 110

7WD40; WD40 repeat [structural motif]

pfam08324
Location:513 → 766

PUL; PUL domain

pfam09070
Location:346 → 459

PFU; PFU (PLAA family ubiquitin binding)