Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Aasdhpptprovided by RGD
Official Full Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseprovided by RGD
Primary source: RGD:1311360
See related: EnsemblRapid:ENSRNOG00000005795 AllianceGenome:RGD:1311360
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable holo-[acyl-carrier-protein] synthase activity and magnesium ion binding activity. Predicted to be involved in lysine biosynthetic process via aminoadipic acid and protein maturation. Predicted to act upstream of with a positive effect on 10-formyltetrahydrofolate catabolic process. Predicted to be active in cytosol. Orthologous to human AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 313.8), Liver (RPKM 309.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (9731592..9748934, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (1453226..1463990, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (1432757..1450175, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables holo-[acyl-carrier-protein] synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables holo-[acyl-carrier-protein] synthase activity	IEA Inferred from Electronic Annotation more info
enables holo-[acyl-carrier-protein] synthase activity	ISO Inferred from Sequence Orthology more info
enables holo-[acyl-carrier-protein] synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 10-formyltetrahydrofolate catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect 10-formyltetrahydrofolate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in lysine biosynthetic process via aminoadipic acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation	IEA Inferred from Electronic Annotation more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Names: 4'-phosphopantetheinyl transferase; AASD-PPT; alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase

NP_001100268.2

EC 2.7.8.7

XP_063121112.1

EC 2.7.8.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106798.2 → NP_001100268.2 L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

See identical proteins and their annotated locations for NP_001100268.2

Status: PROVISIONAL

Source sequence(s)

BC166800

UniProtKB/Swiss-Prot

B2RYJ4

UniProtKB/TrEMBL

A0A8L2Q484

Related

ENSRNOP00000008062.6, ENSRNOT00000008062.9

Conserved Domains (1) summary

COG2091
Location:30 → 205

Sfp; Phosphopantetheinyl transferase [Coenzyme transport and metabolism]