Eipr1 EARP complex and GARP complex interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eipr1provided by RGD
Official Full Name: EARP complex and GARP complex interacting protein 1provided by RGD
Primary source: RGD:1305817
See related: EnsemblRapid:ENSRNOG00000009285 AllianceGenome:RGD:1305817
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tssc1
Summary: Involved in endocytic recycling and regulation of insulin secretion. Predicted to be located in trans-Golgi network. Predicted to be part of EARP complex and GARP complex. Orthologous to human EIPR1 (EARP complex and GARP complex interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 115.1), Thymus (RPKM 93.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (51116827..51230453)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (45388451..45502089)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (48021771..48135241)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128250 (e-PCR)
- UniSTS:211558

D12Ertd604e (e-PCR), detects polymorphism
- UniSTS:167095

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytic recycling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytic recycling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of EARP complex	IEA Inferred from Electronic Annotation more info
part_of EARP complex	ISO Inferred from Sequence Orthology more info
part_of EARP complex	ISS Inferred from Sequence or Structural Similarity more info
part_of GARP complex	IEA Inferred from Electronic Annotation more info
part_of GARP complex	ISO Inferred from Sequence Orthology more info
part_of GARP complex	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: EARP and GARP complex-interacting protein 1

Names: EARP-interacting protein; Golgi-associated retrograde protein-interacting protein; endosome-associated recycling protein-interacting protein; protein TSSC1; tumor suppressing subtransferable candidate 1; tumor-suppressing STF cDNA 1 protein; tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012192.1 → NP_001012192.1 EARP and GARP complex-interacting protein 1

See identical proteins and their annotated locations for NP_001012192.1

Status: PROVISIONAL

Source sequence(s)

BC087633

UniProtKB/Swiss-Prot

Q5PPK9

UniProtKB/TrEMBL

F1LNX7

Related

ENSRNOP00000056930.5, ENSRNOT00000060185.6

Conserved Domains (3) summary

COG2319
Location:39 → 373

WD40; WD40 repeat [General function prediction only]

sd00039
Location:137 → 174

7WD40; WD40 repeat [structural motif]

cl02567
Location:39 → 299

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...