Kcnq5 potassium voltage-gated channel subfamily Q member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcnq5provided by RGD
Official Full Name: potassium voltage-gated channel subfamily Q member 5provided by RGD
Primary source: RGD:628848
See related: EnsemblRapid:ENSRNOG00000013781 AllianceGenome:RGD:628848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kcnq5l
Summary: Enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential and voltage-gated potassium channel activity. Involved in potassium ion transport. Is active in calyx of Held and presynaptic membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 46. Orthologous to human KCNQ5 (potassium voltage-gated channel subfamily Q member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 107.9), Muscle (RPKM 79.4) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (31326595..31892399, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (23830185..24395984, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (27565869..28141114, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea.
Title: KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea.
Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy.
Title: Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy.
KCNQ5-selective activation is a defining molecular mechanistic signature of genetically diverse traditional botanical hypotensives.
Title: KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines.
Downregulated pulmonary expression of KCNQ5 in rat nitrofen-induced congenital diaphragmatic hernia lungs suggests that this potassium channel may play an important role in the development of pulmonary hypertension in this model. KCNQ1 and KCNQ4 expression was not altered.
Title: Downregulation of KCNQ5 expression in the rat pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia.
The high expression and function of Kv7 channels in the left coronary artery and their down-regulation by diabetes critically determine the sensitivity to key regulators of coronary tone.
Title: Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia.
These results show that peripheral activity from auditory nerve afferents is necessary to maintain the subcellular distribution of KCNQ5 in synaptic endings of the auditory brainstem.
Title: Loss of auditory activity modifies the location of potassium channel KCNQ5 in auditory brainstem neurons.
Data indicate that the voltage-gated K(+) channel subfamily member, Kcnq5, mRNA was a target for miR-190.
Title: MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K⁺ channel in arterial smooth muscle cells.
Kv7.1/Kv7.5 form heterotetrameric channels increasing the diversity of structures which fine-tune blood vessel reactivity. The lipid raft localization of Kv7.1/Kv7.5 heteromers provides efficient spatial and temporal regulation of smooth muscle function.
Title: Functional assembly of Kv7.1/Kv7.5 channels with emerging properties on vascular muscle physiology.
In cerebral arteries, Kv7.4 and Kv7.5 proteins exist predominantly as a functional heterotetramer, which regulates intrinsic myogenicity and vasodilation attributed to CGRP.
Title: Contribution of kv7.4/kv7.5 heteromers to intrinsic and calcitonin gene-related peptide-induced cerebral reactivity.
Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.
Title: Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.

Submit: New GeneRIF Correction See all GeneRIFs (22)

General gene information

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Markers

D9Rat180 (e-PCR), detects polymorphism
- UniSTS:228357

D9Got31 (e-PCR)
- UniSTS:114250

RH141099 (e-PCR)
- UniSTS:223096

AU049631 (e-PCR)
- UniSTS:146077

RH138014 (e-PCR)
- UniSTS:220101

RH131959 (e-PCR)
- UniSTS:215242

BE106461 (e-PCR)
- UniSTS:246271

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in calyx of Held	EXP Inferred from Experiment more info	PubMed
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
part_of clathrin coat	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily KQT member 5

Names: potassium channel, voltage-gated KQT-like subfamily Q, member 5; potassium voltage-gated channel, KQT-like subfamily, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134643.2 → NP_001128115.2 potassium voltage-gated channel subfamily KQT member 5

Status: VALIDATED

Source sequence(s)

AI705051, BE103175, BF523361, FQ084615, JAXUCZ010000009

UniProtKB/TrEMBL

A6JJ99, F1LY25

Related

ENSRNOP00000018552.8, ENSRNOT00000018552.10

Conserved Domains (3) summary

pfam00520
Location:159 → 357

Ion_trans; Ion transport protein

pfam03520
Location:471 → 659

KCNQ_channel; KCNQ voltage-gated potassium channel

pfam07885
Location:273 → 347

Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

31326595..31892399 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039083095.2 → XP_038939023.1 potassium voltage-gated channel subfamily KQT member 5 isoform X2

UniProtKB/TrEMBL

A0A8I5ZNI9, A6JJ99

Conserved Domains (2) summary

pfam00520
Location:125 → 357

Ion_trans; Ion transport protein

pfam03520
Location:437 → 625

KCNQ_channel; KCNQ voltage-gated potassium channel
XM_039083094.2 → XP_038939022.1 potassium voltage-gated channel subfamily KQT member 5 isoform X1

UniProtKB/TrEMBL

A0A8I5ZXW9, A6JJ99

Related

ENSRNOP00000084442.1, ENSRNOT00000106244.2

Conserved Domains (2) summary

pfam00520
Location:125 → 357

Ion_trans; Ion transport protein

pfam03520
Location:446 → 634

KCNQ_channel; KCNQ voltage-gated potassium channel
XM_039083097.2 → XP_038939025.1 potassium voltage-gated channel subfamily KQT member 5 isoform X3

Conserved Domains (1) summary

pfam00520
Location:125 → 357

Ion_trans; Ion transport protein