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    Brf1 BRF1 general transcription factor IIIB subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299347, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Brf1provided by RGD
    Official Full Name
    BRF1 general transcription factor IIIB subunitprovided by RGD
    Primary source
    RGD:1311158
    See related
    EnsemblRapid:ENSRNOG00000014595 AllianceGenome:RGD:1311158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase III. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Used to study fibroma. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 RNA polymerase III transcription initiation factor subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 90.6), Thymus (RPKM 83.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Brf1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137854055..137902629, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (132034378..132081313, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137762230..137808573, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene jagged canonical Notch ligand 2 Neighboring gene nudix hydrolase 14 Neighboring gene BTB domain containing 6 Neighboring gene phosphofurin acidic cluster sorting protein 2 Neighboring gene uncharacterized LOC134479482 Neighboring gene uncharacterized LOC134479483

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation. Johnson SA, et al. J Biol Chem, 2008 Jul 11. PMID 18456653, Free PMC Article
    2. Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes. Ernens I, et al. Nucleic Acids Res, 2006. PMID 16407335, Free PMC Article
    3. A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium. Angelis E, et al. Circ Res, 2008 May 23. PMID 18420946, Free PMC Article
    4. Roles of AUF1 isoforms, HuR and BRF1 in ARE-dependent mRNA turnover studied by RNA interference. Raineri I, et al. Nucleic Acids Res, 2004. PMID 14976220, Free PMC Article
    5. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23031840

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase III general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor IIIB 90 kDa subunit
    Names
    BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB
    BRF1, RNA polymerase III transcription initiation factor 90 subunit
    BRF1, RNA polymerase III transcription initiation factor subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399505.1 → NP_001386434.1  transcription factor IIIB 90 kDa subunit

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6KBX3, D4A8W8
      Related
      ENSRNOP00000104047.1, ENSRNOT00000146234.1
      Conserved Domains (2) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:449 → 546
      BRF1; Brf1-like TBP-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      137854055..137902629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112104.2 → XP_038968032.1  transcription factor IIIB 90 kDa subunit isoform X1

      UniProtKB/TrEMBL
      A6KBX3, D4A8W8
      Conserved Domains (2) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:448 → 545
      BRF1; Brf1-like TBP-binding domain

    2. XM_008764931.4 → XP_008763153.1  transcription factor IIIB 90 kDa subunit isoform X2

      Conserved Domains (3) summary
      COG1405
      Location:10 → 118
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]
      pfam07741
      Location:305 → 397
      BRF1; Brf1-like TBP-binding domain
      cl00050
      Location:39 → 112
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    3. XM_017594112.3 → XP_017449601.1  transcription factor IIIB 90 kDa subunit isoform X3

      Conserved Domains (2) summary
      pfam07741
      Location:249 → 341
      BRF1; Brf1-like TBP-binding domain
      cl00050
      Location:3 → 56
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    4. XM_017594111.3 → XP_017449600.1  transcription factor IIIB 90 kDa subunit isoform X3

      Conserved Domains (2) summary
      pfam07741
      Location:249 → 341
      BRF1; Brf1-like TBP-binding domain
      cl00050
      Location:3 → 56
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    5. XM_039112105.2 → XP_038968033.1  transcription factor IIIB 90 kDa subunit isoform X4

      Conserved Domains (1) summary
      COG1405
      Location:4 → 266
      SUA7; Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106761.1: Suppressed sequence

      Description
      NM_001106761.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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