Il34 interleukin 34 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il34provided by RGD
Official Full Name: interleukin 34provided by RGD
Primary source: RGD:1586038
See related: EnsemblRapid:ENSRNOG00000017602 AllianceGenome:RGD:1586038
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and macrophage colony-stimulating factor receptor binding activity. Predicted to be involved in several processes, including interleukin-34-mediated signaling pathway; positive regulation of cell development; and positive regulation of macromolecule metabolic process. Predicted to act upstream of or within positive regulation of MAP kinase activity and positive regulation of protein tyrosine kinase activity. Predicted to be active in extracellular space. Orthologous to human IL34 (interleukin 34). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 98.6), Brain (RPKM 83.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (55624368..55690576, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (38714990..38782749, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (40855537..40905007)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-34 deficiency impairs FOXP3(+) Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis.
Title: IL-34 deficiency impairs FOXP3(+) Treg function in a model of autoimmune colitis and decreases immune tolerance homeostasis.
In a rat cardiac allograft model, IL-34 induced transplant tolerance associated with a total inhibition of alloantibody production. Treatment of rats with IL-34 promoted allograft tolerance mediated by induction of CD8+ and CD4+ Tregs.
Title: IL-34 is a Treg-specific cytokine and mediates transplant tolerance.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127794 (e-PCR)
- UniSTS:211104

BE120045 (e-PCR)
- UniSTS:247232

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables macrophage colony-stimulating factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables macrophage colony-stimulating factor receptor binding	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor binding	ISO Inferred from Sequence Orthology more info
enables macrophage colony-stimulating factor receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-34-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-34-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in microglial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of macrophage proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of monocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: interleukin-34

Names: IL-34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025766.2 → NP_001020937.1 interleukin-34 isoform 1 precursor

See identical proteins and their annotated locations for NP_001020937.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q4KM46

Conserved Domains (1) summary

pfam15036
Location:28 → 183

IL34; Interleukin 34
NM_001434595.1 → NP_001421524.1 interleukin-34 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A140TAD0
NM_001434596.1 → NP_001421525.1 interleukin-34 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A0A140TAD0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

55624368..55690576 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097930.2 → XP_038953858.1 interleukin-34 isoform X1

Conserved Domains (1) summary

pfam15036
Location:28 → 184

IL34; Interleukin 34
XM_039097932.2 → XP_038953860.1 interleukin-34 isoform X2

Conserved Domains (1) summary

pfam15036
Location:28 → 183

IL34; Interleukin 34
XM_063278199.1 → XP_063134269.1 interleukin-34 isoform X1

UniProtKB/TrEMBL

A0A140TAD0

Related

ENSRNOP00000023823.7, ENSRNOT00000023823.9
XM_039097931.2 → XP_038953859.1 interleukin-34 isoform X1

Conserved Domains (1) summary

pfam15036
Location:28 → 184

IL34; Interleukin 34
XM_039097933.2 → XP_038953861.1 interleukin-34 isoform X3

Conserved Domains (1) summary

pfam15036
Location:28 → 182

IL34; Interleukin 34