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    Itgax integrin subunit alpha X [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499271, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Itgaxprovided by RGD
    Official Full Name
    integrin subunit alpha Xprovided by RGD
    Primary source
    RGD:1561123
    See related
    EnsemblRapid:ENSRNOG00000036703 AllianceGenome:RGD:1561123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561123
    Summary
    Predicted to enable integrin binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including integrin-mediated signaling pathway; positive regulation of endothelial tube morphogenesis; and positive regulation of myelination. Predicted to act upstream of or within defense response to virus. Predicted to be located in cell surface. Predicted to be part of integrin alphaX-beta2 complex. Predicted to be active in external side of plasma membrane. Orthologous to human ITGAX (integrin subunit alpha X). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 157.0), Lung (RPKM 72.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Itgax in Genome Data Viewer
    Location:
    1q37
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192140089..192171151)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182709653..182740709)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199555560..199576948)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 140 Neighboring gene integrin subunit alpha M Neighboring gene integrin subunit alpha D Neighboring gene cytochrome c oxidase subunit 6A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel microglial subset plays a key role in myelinogenesis in developing brain. Wlodarczyk A, et al. EMBO J, 2017 Nov 15. PMID 28963396, Free PMC Article
    2. Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. Liu Y, et al. Eur J Immunol, 1992 Nov. PMID 1385153
    3. Integrin alpha x stimulates cancer angiogenesis through PI3K/Akt signaling-mediated VEGFR2/VEGF-A overexpression in blood vessel endothelial cells. Wang J, et al. J Cell Biochem, 2019 Feb. PMID 30873824
    4. Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Yokota A, et al. Microbiol Immunol, 2003. PMID 12801066
    5. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Dai YD, et al. Diabetes, 2009 Jan. PMID 18984740, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    NOT acts_upstream_of_or_within activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrin alphaX-beta2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    integrin alpha-X
    Names
    integrin, alpha X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419757.1 → NP_001406686.1  integrin alpha-X precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I9Y3, D3ZWZ1
      Related
      ENSRNOP00000083288.2, ENSRNOT00000099518.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      192140089..192171151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101230.2 → XP_038957158.1  integrin alpha-X isoform X1

      UniProtKB/TrEMBL
      A6I9Y3
      Related
      ENSRNOP00000051866.5, ENSRNOT00000054983.6
      Conserved Domains (3) summary
      smart00191
      Location:460 → 515
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:93 → 268
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:558 → 983
      Integrin_alpha2; Integrin alpha

    2. XM_039101233.2 → XP_038957161.1  integrin alpha-X isoform X4

      Conserved Domains (1) summary
      cl00057
      Location:150 → 242
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. XM_039101231.1 → XP_038957159.1  integrin alpha-X isoform X2

      Conserved Domains (3) summary
      smart00191
      Location:243 → 298
      Int_alpha; Integrin alpha (beta-propellor repeats)
      pfam08441
      Location:341 → 766
      Integrin_alpha2; Integrin alpha
      cl00057
      Location:1 → 51
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. XM_063271412.1 → XP_063127482.1  integrin alpha-X isoform X3

    RNA

    1. XR_005499481.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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