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    Srsf7 serine and arginine rich splicing factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362687, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Srsf7provided by RGD
    Official Full Name
    serine and arginine rich splicing factor 7provided by RGD
    Primary source
    RGD:1307425
    See related
    EnsemblRapid:ENSRNOG00000027360 AllianceGenome:RGD:1307425
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sfrs7
    Summary
    Predicted to enable mRNA binding activity and protein domain specific binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome and negative regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Orthologous to human SRSF7 (serine and arginine rich splicing factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 461.6), Spleen (RPKM 311.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srsf7 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20564035..20571205)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14811775..14818968)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (2879312..2886505, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene gem (nuclear organelle) associated protein 6 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene galactose mutarotase Neighboring gene uncharacterized LOC134479103 Neighboring gene uncharacterized LOC134479102

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family. Cavaloc Y, et al. EMBO J, 1994 Jun 1. PMID 8013463, Free PMC Article
    2. Screening for genes up-regulated in 5/6 nephrectomized mouse kidney. Zhang H, et al. Kidney Int, 1999 Aug. PMID 10432394
    3. Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors. Piekielko-Witkowska A, et al. PLoS One, 2010 Oct 27. PMID 21082031, Free PMC Article
    4. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. Wang J, et al. J Neurochem, 2004 Mar. PMID 15009664
    5. RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing. Venables JP, et al. Hum Mol Genet, 2000 Mar 22. PMID 10749975

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116344

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 7
    Names
    splicing factor, arginine/serine-rich 7, 35kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039035.2 → NP_001034124.2  serine/arginine-rich splicing factor 7

      See identical proteins and their annotated locations for NP_001034124.2

      Status: VALIDATED

      Source sequence(s)
      FM079490, FM084661, FM085512, FM092264, JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AFZ5, A0A8I6ALL8, A6H9R6
      Related
      ENSRNOP00000091604.1, ENSRNOT00000097127.2
      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      20564035..20571205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239644.2 → XP_006239706.1  serine/arginine-rich splicing factor 7 isoform X3

      See identical proteins and their annotated locations for XP_006239706.1

      UniProtKB/TrEMBL
      A6H9R7, A6H9R9, D4A720
      Related
      ENSRNOP00000035155.4, ENSRNOT00000038448.7
      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    2. XM_006239642.2 → XP_006239704.1  serine/arginine-rich splicing factor 7 isoform X1

      See identical proteins and their annotated locations for XP_006239704.1

      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    3. XM_006239645.2 → XP_006239707.1  serine/arginine-rich splicing factor 7 isoform X4

      See identical proteins and their annotated locations for XP_006239707.1

      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    4. XM_006239643.2 → XP_006239705.1  serine/arginine-rich splicing factor 7 isoform X2

      See identical proteins and their annotated locations for XP_006239705.1

      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    5. XM_006239646.2 → XP_006239708.1  serine/arginine-rich splicing factor 7 isoform X5

      See identical proteins and their annotated locations for XP_006239708.1

      UniProtKB/TrEMBL
      A0A8I6ALL8, A6H9R8
      Conserved Domains (1) summary
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    6. XM_039112457.2 → XP_038968385.1  serine/arginine-rich splicing factor 7 isoform X7

      UniProtKB/TrEMBL
      A0A8I5YB97, A6H9S1, Q4KLJ1
      Conserved Domains (2) summary
      smart00343
      Location:105 → 119
      ZnF_C2HC; zinc finger
      cd12646
      Location:12 → 88
      RRM_SRSF7; RNA recognition motif (RRM) found in vertebrate serine/arginine-rich splicing factor 7 (SRSF7)

    7. XM_039112458.2 → XP_038968386.1  serine/arginine-rich splicing factor 7 isoform X8

      Related
      ENSRNOP00000104476.1, ENSRNOT00000151137.1

    8. XM_063262047.1 → XP_063118117.1  serine/arginine-rich splicing factor 7 isoform X9

    9. XM_063262046.1 → XP_063118116.1  serine/arginine-rich splicing factor 7 isoform X6

    RNA

    1. XR_010052100.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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