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    Mir351 microRNA 351 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100314289, updated on 17-Aug-2024

    Summary

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    Symbol
    Mir351provided by RGD
    Full Name
    microRNA 351provided by RGD
    Primary source
    RGD:2325338
    See related
    miRBase:MI0000642; AllianceGenome:RGD:2325338
    Gene type
    ncRNA
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mir351-1; rno-mir-351; rno-mir-351-1
    Summary
    microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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    Genomic context

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    See Mir351 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (137725116..137725196, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (132805563..132805643, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (158149206..158149286)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene microRNA mir-450b-1 Neighboring gene microRNA 542 Neighboring gene uncharacterized LOC102550366 Neighboring gene microRNA 503 Neighboring gene microRNA 322

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p. Yao QP, et al. J Cell Physiol, 2020 Oct. PMID 31990052
    2. miR-351-3p promotes rat amniotic fluid-derived mesenchymal stromal cell proliferation via targeting the coding sequence of Abca4. Huang J, et al. Stem Cells, 2021 Sep. PMID 33970551
    3. Mir-351-5p contributes to the establishment of a pro-inflammatory environment in the H9c2 cell line by repressing PTEN expression. da Silva W, et al. Mol Cell Biochem, 2016 Jan. PMID 26541756
    4. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Kim J, et al. Proc Natl Acad Sci U S A, 2004 Jan 6. PMID 14691248, Free PMC Article
    5. Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Watanabe T, et al. Genes Dev, 2006 Jul 1. PMID 16766679, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-351-3p promotes rat amniotic fluid-derived mesenchymal stromal cell proliferation via targeting the coding sequence of Abca4.
      Title: miR-351-3p promotes rat amniotic fluid-derived mesenchymal stromal cell proliferation via targeting the coding sequence of Abca4.
    2. Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p.
      Title: Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p.
    3. cellular model of investigation was established and the miR-315-5p was identified as a novel element targeting PTEN in this cardiac cell line, thereby controlling the protein level
      Title: Mir-351-5p contributes to the establishment of a pro-inflammatory environment in the H9c2 cell line by repressing PTEN expression.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Other Names

    • microRNA mir-351
    • microRNA mir-351-1
    • microRNA mir-351-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_031796.1 RNA Sequence

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      137725116..137725196 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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