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    Pank1 pantothenate kinase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pank1provided by RGD
    Official Full Name
    pantothenate kinase 1provided by RGD
    Primary source
    RGD:1304677
    See related
    EnsemblRapid:ENSRNOG00000018944 AllianceGenome:RGD:1304677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable acetyl-CoA binding activity; pantothenate kinase activity; and protein homodimerization activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in cell periphery and cytoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human PANK1 (pantothenate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 178.0), Kidney (RPKM 150.3) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pank1 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (241737371..241808126, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (232324718..232395445, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (253115400..253189643, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 16, member 12 Neighboring gene uncharacterized LOC134485224 Neighboring gene microRNA 107 Neighboring gene uncharacterized LOC102549070 Neighboring gene kinesin family member 20B Neighboring gene glutamyl-tRNA synthetase 2-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The murine pantothenate kinase (Pank1) gene encodes two differentially regulated pantothenate kinase isozymes. Rock CO, et al. Gene, 2002 May 29. PMID 12095677
    2. Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state. Leonardi R, et al. PLoS One, 2010 Jun 14. PMID 20559429, Free PMC Article
    3. The ADAM1a and ADAM1b genes, instead of the ADAM1 (fertilin alpha) gene, are localized on mouse chromosome 5. Nishimura H, et al. Gene, 2002 May 29. PMID 12095680
    4. Feedback regulation of murine pantothenate kinase 3 by coenzyme A and coenzyme A thioesters. Zhang YM, et al. J Biol Chem, 2005 Sep 23. PMID 16040613
    5. Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder. Hong BS, et al. J Biol Chem, 2007 Sep 21. PMID 17631502

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pantothenate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pantothenate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pantothenate kinase 1
    NP_001099843.1
    XP_006231338.1
    XP_006231339.1
    XP_006231340.1
    XP_038965184.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106373.3 → NP_001099843.1  pantothenate kinase 1

      See identical proteins and their annotated locations for NP_001099843.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I139, A6I140, D3ZWD3
      Related
      ENSRNOP00000063874.1, ENSRNOT00000067822.4
      Conserved Domains (1) summary
      pfam03630
      Location:14 → 362
      Fumble

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      241737371..241808126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231277.5 → XP_006231339.1  pantothenate kinase 1 isoform X2

      Conserved Domains (1) summary
      pfam03630
      Location:191 → 480
      Fumble; Fumble

    2. XM_006231276.4 → XP_006231338.1  pantothenate kinase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUU2
      Related
      ENSRNOP00000082596.1, ENSRNOT00000100218.2
      Conserved Domains (1) summary
      pfam03630
      Location:191 → 539
      Fumble; Fumble

    3. XM_039109256.2 → XP_038965184.1  pantothenate kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G9G6
      Related
      ENSRNOP00000083785.1, ENSRNOT00000096368.2
      Conserved Domains (1) summary
      pfam03630
      Location:25 → 257
      Fumble

    4. XM_006231278.5 → XP_006231340.1  pantothenate kinase 1 isoform X3

      UniProtKB/TrEMBL
      A6I139
      Conserved Domains (1) summary
      pfam03630
      Location:1 → 347
      Fumble
    Nucleotide Protein Strain
    Heading Accession and Version

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