Dnaaf1 dynein, axonemal, assembly factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnaaf1provided by RGD
Official Full Name: dynein, axonemal, assembly factor 1provided by RGD
Primary source: RGD:1310542
See related: EnsemblRapid:ENSRNOG00000015590 AllianceGenome:RGD:1310542
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lrrc50; RGD1310542
Summary: Predicted to enable dynein complex binding activity. Predicted to be involved in several processes, including cilium assembly; determination of left/right symmetry; and regulation of cilium beat frequency. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 13. Orthologous to human DNAAF1 (dynein axonemal assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 813.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (64532859..64560942)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (47624534..47652314)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (52217427..52245930)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI145291 (e-PCR)
- UniSTS:261127

RH134909 (e-PCR)
- UniSTS:218187

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein complex binding	IEA Inferred from Electronic Annotation more info
enables dynein complex binding	ISO Inferred from Sequence Orthology more info
enables dynein complex binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axonemal dynein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in axoneme assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium movement	IEA Inferred from Electronic Annotation more info
involved_in cilium movement	ISO Inferred from Sequence Orthology more info
involved_in determination of digestive tract left/right asymmetry	IEA Inferred from Electronic Annotation more info
involved_in determination of digestive tract left/right asymmetry	ISO Inferred from Sequence Orthology more info
involved_in determination of liver left/right asymmetry	IEA Inferred from Electronic Annotation more info
involved_in determination of liver left/right asymmetry	ISO Inferred from Sequence Orthology more info
involved_in determination of pancreatic left/right asymmetry	IEA Inferred from Electronic Annotation more info
involved_in determination of pancreatic left/right asymmetry	ISO Inferred from Sequence Orthology more info
involved_in heart looping	IEA Inferred from Electronic Annotation more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
involved_in inner dynein arm assembly	IEA Inferred from Electronic Annotation more info
involved_in inner dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in left/right pattern formation	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEA Inferred from Electronic Annotation more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
involved_in motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in outer dynein arm assembly	IEA Inferred from Electronic Annotation more info
involved_in outer dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cilium beat frequency	IEA Inferred from Electronic Annotation more info
involved_in regulation of cilium beat frequency	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein axonemal assembly factor 1

Names: dynein assembly factor 1, axonemal; leucine rich repeat containing 50; leucine-rich repeat-containing protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014154.1 → NP_001014176.1 dynein axonemal assembly factor 1

See identical proteins and their annotated locations for NP_001014176.1

Status: PROVISIONAL

Source sequence(s)

BC079038

UniProtKB/Swiss-Prot

Q6AYH9

UniProtKB/TrEMBL

A0A8I6A474, A6IZJ4

Related

ENSRNOP00000020917.3, ENSRNOT00000020917.6

Conserved Domains (3) summary

cd00116
Location:116 → 252

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:105 → 124

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:145 → 201

LRR_8; Leucine rich repeat