Traf3ip1 TRAF3 interacting protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Traf3ip1provided by RGD
Official Full Name: TRAF3 interacting protein 1provided by RGD
Primary source: RGD:1309252
See related: EnsemblRapid:ENSRNOG00000024468 AllianceGenome:RGD:1309252
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MIP-T3
Summary: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including cilium organization; negative regulation of macromolecule metabolic process; and regulation of microtubule cytoskeleton organization. Predicted to act upstream of or within several processes, including embryonic organ development; negative regulation of interferon-beta production; and post-anal tail morphogenesis. Predicted to be located in several cellular components, including centrosome; ciliary base; and ciliary tip. Predicted to be part of intraciliary transport particle B. Predicted to be active in axoneme and ciliary basal body. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Orthologous to human TRAF3IP1 (TRAF3 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 60.6), Kidney (RPKM 48.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (99521176..99557966)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (92073622..92110427)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (98621499..98658223)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables microtubule binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic camera-type eye development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic heart tube development	ISO Inferred from Sequence Orthology more info
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISS Inferred from Sequence or Structural Similarity more info
involved_in morphogenesis of a polarized epithelium	IEA Inferred from Electronic Annotation more info
involved_in morphogenesis of a polarized epithelium	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of a polarized epithelium	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of defense response to virus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube patterning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-anal tail morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in axoneme	IBA Inferred from Biological aspect of Ancestor more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary base	IEA Inferred from Electronic Annotation more info
located_in ciliary base	ISO Inferred from Sequence Orthology more info
located_in ciliary base	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary tip	IEA Inferred from Electronic Annotation more info
located_in ciliary tip	ISO Inferred from Sequence Orthology more info
located_in ciliary tip	ISS Inferred from Sequence or Structural Similarity more info
located_in ciliary transition zone	IEA Inferred from Electronic Annotation more info
located_in ciliary transition zone	ISO Inferred from Sequence Orthology more info
located_in ciliary transition zone	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle B	ISO Inferred from Sequence Orthology more info
part_of intraciliary transport particle B	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TRAF3-interacting protein 1

Names: TNF receptor-associated factor 3 interacting protein 1; intraflagellar transport protein 54 homolog; microtubule-interacting protein associated with TRAF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012204.1 → NP_001012204.1 TRAF3-interacting protein 1

See identical proteins and their annotated locations for NP_001012204.1

Status: PROVISIONAL

Source sequence(s)

BC083645

UniProtKB/Swiss-Prot

Q5XIN3

UniProtKB/TrEMBL

A0A8I5ZJ93

Related

ENSRNOP00000076695.2, ENSRNOT00000104108.2

Conserved Domains (2) summary

PTZ00438
Location:151 → 208

PTZ00438; gamete antigen 27/25-like protein; Provisional

pfam10243
Location:49 → 647

MIP-T3; Microtubule-binding protein MIP-T3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

99521176..99557966

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245437.5 → XP_006245499.2 TRAF3-interacting protein 1 isoform X5

UniProtKB/TrEMBL

A0A8I5Y0E3, A0A8I5ZJ93

Conserved Domains (2) summary

PTZ00438
Location:151 → 208

PTZ00438; gamete antigen 27/25-like protein; Provisional

pfam10243
Location:49 → 618

MIP-T3; Microtubule-binding protein MIP-T3
XM_017596540.3 → XP_017452029.1 TRAF3-interacting protein 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JWM5, A0A8I5ZJ93

Related

ENSRNOP00000069939.1, ENSRNOT00000081992.3
XM_006245435.5 → XP_006245497.2 TRAF3-interacting protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I5ZJ93, A0A8I5ZYG8

Related

ENSRNOP00000085077.1, ENSRNOT00000100401.2

Conserved Domains (2) summary

PTZ00438
Location:151 → 208

PTZ00438; gamete antigen 27/25-like protein; Provisional

pfam10243
Location:49 → 615

MIP-T3; Microtubule-binding protein MIP-T3
XM_006245436.5 → XP_006245498.2 TRAF3-interacting protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I5ZJ93

Related

ENSRNOP00000076805.2, ENSRNOT00000113396.2

Conserved Domains (2) summary

PTZ00438
Location:151 → 208

PTZ00438; gamete antigen 27/25-like protein; Provisional

pfam10243
Location:49 → 594

MIP-T3; Microtubule-binding protein MIP-T3
XM_039083925.2 → XP_038939853.1 TRAF3-interacting protein 1 isoform X4

Conserved Domains (1) summary

pfam17749
Location:226 → 380

MIP-T3_C; Microtubule-binding protein MIP-T3 C-terminal region