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    Ptrh1 peptidyl-tRNA hydrolase 1 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362113, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptrh1provided by RGD
    Official Full Name
    peptidyl-tRNA hydrolase 1 homologprovided by RGD
    Primary source
    RGD:1310165
    See related
    EnsemblRapid:ENSRNOG00000049034 AllianceGenome:RGD:1310165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310165
    Summary
    Predicted to enable aminoacyl-tRNA hydrolase activity. Predicted to be involved in rescue of stalled ribosome. Predicted to be located in mitochondrion. Orthologous to human PTRH1 (peptidyl-tRNA hydrolase 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 54.9), Lung (RPKM 47.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptrh1 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36462575..36475605)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (16064867..16071098)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11811303..11817007)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 3C Neighboring gene RNA, U6 small nuclear 899 Neighboring gene torsin family 2, member A Neighboring gene tetratricopeptide repeat domain 16 Neighboring gene cilia and flagella associated protein 157 Neighboring gene syntaxin binding protein 1 Neighboring gene uncharacterized LOC134486073 Neighboring gene niban apoptosis regulator 2 Neighboring gene leucine rich repeat and sterile alpha motif containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidyl-tRNA hydrolase
    Names
    probable peptidyl-tRNA hydrolase
    XP_038962111.2
    XP_063140142.1
    XP_063140144.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399255.2 → NP_001386184.2  peptidyl-tRNA hydrolase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JU87, D3ZI43
      Related
      ENSRNOP00000032989.6, ENSRNOT00000039151.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36462575..36475605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284072.1 → XP_063140142.1  peptidyl-tRNA hydrolase isoform X1

    2. XM_039106183.2 → XP_038962111.2  peptidyl-tRNA hydrolase isoform X2

    3. XM_063284074.1 → XP_063140144.1  peptidyl-tRNA hydrolase isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108580.1: Suppressed sequence

      Description
      NM_001108580.1: This RefSeq was suppressed temporarily pending review of supporting evidence.
    Nucleotide Protein Strain
    Heading Accession and Version

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