Elf5 E74 like ETS transcription factor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Elf5provided by RGD
Official Full Name: E74 like ETS transcription factor 5provided by RGD
Primary source: RGD:1305859
See related: EnsemblRapid:ENSRNOG00000008282 AllianceGenome:RGD:1305859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including ectodermal cell fate commitment; mammary gland epithelial cell differentiation; and negative regulation of cell differentiation involved in embryonic placenta development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human ELF5 (E74 like ETS transcription factor 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 14.4), Kidney (RPKM 4.6) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (110264460..110291926)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (89808837..89836977)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (93333514..93374454)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D3Rat205 (e-PCR), detects polymorphism
- UniSTS:227593

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ectoderm development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ectodermal cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell differentiation involved in embryonic placenta development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of trophoblast giant cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ETS-related transcription factor Elf-5

Names: E74-like factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108956.2 → NP_001102426.1 ETS-related transcription factor Elf-5

See identical proteins and their annotated locations for NP_001102426.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HNR4, D4A3N9

Related

ENSRNOP00000011035.5, ENSRNOT00000011035.7

Conserved Domains (2) summary

cd08538
Location:39 → 122

SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators

smart00413
Location:162 → 246

ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

110264460..110291926

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008762070.3 → XP_008760292.1 ETS-related transcription factor Elf-5 isoform X1

UniProtKB/TrEMBL

A0A8I6A588, D4A3N9

Related

ENSRNOP00000087846.1, ENSRNOT00000095913.2

Conserved Domains (2) summary

smart00413
Location:163 → 247

ETS; erythroblast transformation specific domain

cl15755
Location:42 → 123

SAM_superfamily; SAM (Sterile alpha motif )