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    Enox2 ecto-NOX disulfide-thiol exchanger 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302817, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Enox2provided by RGD
    Official Full Name
    ecto-NOX disulfide-thiol exchanger 2provided by RGD
    Primary source
    RGD:1563643
    See related
    EnsemblRapid:ENSRNOG00000030622 AllianceGenome:RGD:1563643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cova1; RGD1563643
    Summary
    Predicted to enable RNA binding activity and oxidoreductase activity. Predicted to be involved in electron transport chain and ultradian rhythm. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human ENOX2 (ecto-NOX disulfide-thiol exchanger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 28.1), Muscle (RPKM 21.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Enox2 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (133148813..133470914, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (128270941..128593074, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (135918938..136303267, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 49 Neighboring gene fibrous sheath-interacting protein 2 like 1 Neighboring gene eukaryotic translation initiation factor 4B-like Neighboring gene Rho GTPase activating protein 36 Neighboring gene high mobility group protein B4-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biochemical basis for the biological clock. Morré DJ, et al. Biochemistry, 2002 Oct 8. PMID 12356293
    2. Molecular cloning and characterization of a tumor-associated, growth-related, and time-keeping hydroquinone (NADH) oxidase (tNOX) of the HeLa cell surface. Chueh PJ, et al. Biochemistry, 2002 Mar 19. PMID 11888291
    3. Surface NADH oxidase of HeLa cells lacks intrinsic membrane binding motifs. Morré DJ, et al. Arch Biochem Biophys, 2001 Aug 15. PMID 11488599
    4. [Mitral valve aneurysm associated with mitral insufficiency in absence of aortic insufficiency]. Tarasoutchi F, et al. Arq Bras Cardiol, 1991 Mar. PMID 1888291
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in electron transport chain ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ultradian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ecto-NOX disulfide-thiol exchanger 2
    Names
    cytosolic ovarian carcinoma antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427048.1 → NP_001413977.1  ecto-NOX disulfide-thiol exchanger 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A1W2Q6P9, A6JMR8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      133148813..133470914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602398.3 → XP_017457887.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0A1W2Q6I1, A0A1W2Q6P9, A6JMR6, A6JMR8
      Conserved Domains (2) summary
      COG0724
      Location:90 → 168
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12228
      Location:93 → 176
      RRM_ENOX; RNA recognition motif (RRM) in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    2. XM_039100556.2 → XP_038956484.1  ecto-NOX disulfide-thiol exchanger 2 isoform X4

      UniProtKB/TrEMBL
      A0A1W2Q6P9, A6JMR8
      Related
      ENSRNOP00000076336.2, ENSRNOT00000093636.3
      Conserved Domains (1) summary
      cd12228
      Location:108 → 191
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    3. XM_063279958.1 → XP_063136028.1  ecto-NOX disulfide-thiol exchanger 2 isoform X5

      UniProtKB/TrEMBL
      A0A1W2Q6I1, A0A1W2Q6P9, A6JMR6, A6JMR8
      Related
      ENSRNOP00000076284.1, ENSRNOT00000093185.3

    4. XM_008773547.4 → XP_008771769.2  ecto-NOX disulfide-thiol exchanger 2 isoform X2

      UniProtKB/TrEMBL
      A0A1W2Q6P9, A6JMR8

    5. XM_039100555.2 → XP_038956483.1  ecto-NOX disulfide-thiol exchanger 2 isoform X3

      UniProtKB/TrEMBL
      A0A1W2Q6P9, A6JMR8, D3Z9Z5
      Related
      ENSRNOP00000107492.1, ENSRNOT00000126815.1
      Conserved Domains (1) summary
      cd12228
      Location:113 → 196
      RRM_ENOX; RNA recognition motif (RRM) found in the cell surface Ecto-NOX disulfide-thiol exchanger (ECTO-NOX or ENOX) proteins

    6. XM_017602395.3 → XP_017457884.1  ecto-NOX disulfide-thiol exchanger 2 isoform X1

      UniProtKB/TrEMBL
      A0A1W2Q6P9, A6JMR8
      Related
      ENSRNOP00000110104.1, ENSRNOT00000166892.1
    Nucleotide Protein Strain
    Heading Accession and Version

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