Eda ectodysplasin-A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Edaprovided by RGD
Official Full Name: ectodysplasin-Aprovided by RGD
Primary source: RGD:1563178
See related: EnsemblRapid:ENSRNOG00000032208 AllianceGenome:RGD:1563178
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tnlg7c; RGD1563178
Summary: Predicted to enable cytokine activity; death receptor agonist activity; and death receptor binding activity. Predicted to be involved in animal organ development; cytokine-mediated signaling pathway; and regulation of non-canonical NF-kappaB signal transduction. Predicted to act upstream of or within several processes, including hair follicle placode formation; positive regulation of signal transduction; and trachea gland development. Predicted to be located in several cellular components, including apical part of cell; endoplasmic reticulum membrane; and lipid droplet. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 28.1), Muscle (RPKM 19.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (69118577..69520274)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (65078454..65480172)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (69730123..70222693)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ectodysplasin-A mRNA in exosomes released from activated hepatic stellate cells stimulates macrophage response.
Title: Ectodysplasin-A mRNA in exosomes released from activated hepatic stellate cells stimulates macrophage response.

Submit: New GeneRIF Correction

General gene information

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Markers

PMC24264P3 (e-PCR)
- UniSTS:272247

PMC24264P4 (e-PCR)
- UniSTS:272248

AU049644 (e-PCR)
- UniSTS:146090

AU025000 (e-PCR)
- UniSTS:115695

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables death receptor agonist activity	ISO Inferred from Sequence Orthology more info
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables tumor necrosis factor receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle placode formation	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within salivary gland cavitation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trachea gland development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ectodysplasin-A

Names: tumor necrosis factor ligand 7c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305243.1 → NP_001292172.1 ectodysplasin-A

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A096MIW0, A0A096MJ56

Related

ENSRNOP00000067898.2, ENSRNOT00000076425.3

Conserved Domains (1) summary

cd00184
Location:249 → 383

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

69118577..69520274

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099598.2 → XP_038955526.1 ectodysplasin-A isoform X5

Conserved Domains (1) summary

cl00147
Location:249 → 307

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
XM_008773301.4 → XP_008771523.1 ectodysplasin-A isoform X4

See identical proteins and their annotated locations for XP_008771523.1

UniProtKB/TrEMBL

A0A096MJ56

Conserved Domains (1) summary

cl00147
Location:249 → 369

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
XM_006257112.5 → XP_006257174.1 ectodysplasin-A isoform X2

See identical proteins and their annotated locations for XP_006257174.1

UniProtKB/TrEMBL

A0A096MJ56

Conserved Domains (1) summary

cd00184
Location:249 → 380

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
XM_228582.11 → XP_228582.6 ectodysplasin-A isoform X3

See identical proteins and their annotated locations for XP_228582.6

UniProtKB/TrEMBL

A0A096MJ56

Conserved Domains (1) summary

cd00184
Location:249 → 378

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
XM_006257111.5 → XP_006257173.1 ectodysplasin-A isoform X1

See identical proteins and their annotated locations for XP_006257173.1

UniProtKB/TrEMBL

A0A096MJ56, A0A0U5J6T2

Conserved Domains (1) summary

cd00184
Location:249 → 381

TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...