Nkx2-2 NK2 homeobox 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nkx2-2provided by RGD
Official Full Name: NK2 homeobox 2provided by RGD
Primary source: RGD:1308443
See related: AllianceGenome:RGD:1308443
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in optic nerve development; response to glucose; and response to progesterone. Predicted to be active in nucleus. Biomarker of demyelinating disease. Orthologous to human NKX2-2 (NK2 homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 16.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (155072621..155083699, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (134619701..134630282, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (141408460..141419083, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nkx2.2 targeted to the pancreas by UTMD induces pancreatic progenitor cell proliferation and differentiation with subsequent islet regeneration and cure of STZ-induced diabetes for three months.
Title: Ectopic transgenic expression of NKX2.2 induces differentiation of adult pancreatic progenitors and mediates islet regeneration.
Nkx2.2 is one of the essential transcription factors delivering the specificity of JN promoter in oligodendrocytes.
Title: Identification of Juxtanodin promoter and its transcriptional regulation during the ATRA-induced differentiation of C6 cells.
These results suggest that environmental factors such as cytokines may affect Nkx2.2 expression or oligodendrocyte precursor cell differentiation in the contusion-induced spinal cord injury model.
Title: Nkx2.2 expression in differentiation of oligodendrocyte precursor cells and inhibitory factors for differentiation of oligodendrocytes after traumatic spinal cord injury.
prevents the precocious expression of myelin basic protein in immature oligodendrocytes
Title: Stage-specific expression of myelin basic protein in oligodendrocytes involves Nkx2.2-mediated repression that is relieved by the Sp1 transcription factor.
At 7 dpi, a significant up-regulation of Nkx2.2 by OPCs within the lesion was observed, 90% of which coexpressed NG2 and virtually all of which coexpressed the bHLH transcription factor Olig2.
Title: Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes.
Increased expression of Nkx2.2 plays a critically important role in the differentiation of adult oligodendrocyte progenitor cells into remyelinating oligodendrocytes.
Title: Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS.
The process of generating new oligodendrocytes (OLs) in a remyelinating lesion recapitulates the developmental program involving activation of the Nkx2.2 gene.
Title: Transient upregulation of Nkx2.2 expression in oligodendrocyte lineage cells during remyelination.

Submit: New GeneRIF Correction

General gene information

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Markers

D3Ztm2 (e-PCR)
- UniSTS:517927

UniSTS:238165 (e-PCR)
- UniSTS:238165

Nkx2-2 (e-PCR), detects polymorphism
- UniSTS:238165

PMC123023P4 (e-PCR)
- UniSTS:270425

Nkx2-2 (e-PCR), detects polymorphism
- UniSTS:144023

Nkx2-2 (e-PCR), detects polymorphism
- UniSTS:516529

Nkx2-2 (e-PCR), detects polymorphism
- UniSTS:536534

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within astrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell development	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within digestive tract development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endocrine pancreas development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroendocrine cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within pancreatic A cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pancreatic PP cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord oligodendrocyte cell fate specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within type B pancreatic cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of type B pancreatic cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within type B pancreatic cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventral spinal cord interneuron fate determination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homeobox protein Nkx-2.2

Names: NK2 transcription factor related, locus 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191904.1 → NP_001178833.1 homeobox protein Nkx-2.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

D3ZDQ2

Conserved Domains (1) summary

pfam00046
Location:131 → 185

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

155072621..155083699 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105602.2 → XP_038961530.1 homeobox protein Nkx-2.2 isoform X1

UniProtKB/TrEMBL

D3ZDQ2

Conserved Domains (1) summary

pfam00046
Location:131 → 185

Homeobox; Homeobox domain
XM_017591951.3 → XP_017447440.1 homeobox protein Nkx-2.2 isoform X1

UniProtKB/TrEMBL

D3ZDQ2

Conserved Domains (1) summary

pfam00046
Location:131 → 185

Homeobox; Homeobox domain