Vegfd vascular endothelial growth factor D [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vegfdprovided by RGD
Official Full Name: vascular endothelial growth factor Dprovided by RGD
Primary source: RGD:620695
See related: EnsemblRapid:ENSRNOG00000003587 AllianceGenome:RGD:620695
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Figf; Vegf-d
Summary: Enables vascular endothelial growth factor receptor binding activity. Involved in several processes, including positive regulation of interleukin-6 production; regulation of vascular endothelial growth factor receptor signaling pathway; and response to interleukin-1. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human VEGFD (vascular endothelial growth factor D). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 85.4), Kidney (RPKM 57.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (33704582..33740305, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (30073122..30108413, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (31816480..31852239, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of VEGF-D and its receptor, VEGFR-3, are enhanced in various cell types in the infarcted heart.
Title: Differential expression of vascular endothelial growth factor isoforms and receptor subtypes in the infarcted heart.
Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo.
Title: Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo.
VEGF-D expression may have a role in interleukin (IL)-6 expression and transcription factor AP-1 activation in pancreatic acinar cells.
Title: Role of vascular endothelial growth factor-D (VEGF-D) on IL-6 expression in cerulein-stimulated pancreatic acinar cells.
Overexpression of VEGF-D is associated with Gliosarcomas
Title: Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-D.

Submit: New GeneRIF Correction

General gene information

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Markers

Figf (e-PCR), detects polymorphism
- UniSTS:470539

MARC_21748-21749:1023808694:5 (e-PCR)
- UniSTS:268624

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
NOT enables vascular endothelial growth factor receptor 2 binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 3 binding	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor 3 binding	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables vascular endothelial growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in fibroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in induction of positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in induction of positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mast cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in vascular endothelial growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vascular endothelial growth factor D

Names: c-fos-induced growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434266.1 → NP_001421195.1 vascular endothelial growth factor D precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

O35251, Q91ZE4

UniProtKB/TrEMBL

A6K2L1
NM_031761.3 → NP_113949.2 vascular endothelial growth factor D precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

O35251, Q91ZE4

UniProtKB/TrEMBL

A6K2L1

Related

ENSRNOP00000058883.3, ENSRNOT00000068601.4

Conserved Domains (1) summary

smart00141
Location:114 → 198

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

33704582..33740305 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280111.1 → XP_063136181.1 vascular endothelial growth factor D isoform X2

UniProtKB/Swiss-Prot

O35251, Q91ZE4

UniProtKB/TrEMBL

G3V9S8

Related

ENSRNOP00000104705.1, ENSRNOT00000152015.1
XM_063280112.1 → XP_063136182.1 vascular endothelial growth factor D isoform X3

UniProtKB/Swiss-Prot

O35251, Q91ZE4
XM_006256863.5 → XP_006256925.1 vascular endothelial growth factor D isoform X1

Conserved Domains (1) summary

smart00141
Location:114 → 198

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family