Klk1 kallikrein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klk1provided by RGD
Official Full Name: kallikrein 1provided by RGD
Primary source: RGD:2969
See related: EnsemblRapid:ENSRNOG00000068378 AllianceGenome:RGD:2969
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kal; KALA; Klk5; Klk7; Klk1l; Klna3; RGK-7; Klk1c7; RSKG-7; RATKALA
Summary: Enables endopeptidase activity. Involved in several processes, including positive regulation of acute inflammatory response; positive regulation of apoptotic process; and response to nutrient. Located in acrosomal vesicle and apical part of cell. Biomarker of hypertension and pancreatitis. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to human KLK1 (kallikrein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 1188.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (103779152..103783270)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (94642644..94646760)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (100131562..100135556)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coexpression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemiareperfusion injury by promoting angiogenesis and inhibiting oxidative stress.
Title: Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress.
these findings suggest that urinary kallidinogenase attenuated flap ischemia and increased the survival of random skin flaps in rats
Title: Effects and mechanism of urinary kallidinogenase in the survival of random skin flaps in rats.
Tissue kallikrein 1 and TIMP1 expressed in a coexpression vector synergistically inhibited the proliferation of rat vascular smooth muscle cells.
Title: Synergistic effect of a tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 co‑expression vector on the proliferation of rat vascular smooth muscle cells.
Gonadectomy influences blood pressure through the kallikrein-kinin system.
Title: Gonadectomy influences blood pressure through the kallikrein-kinin system.
Kal7 plays an essential role in synaptic structure and function, affecting a subset of cognitive processes.
Title: Kalirin-7 is required for synaptic structure and function.
Plasma kallikrein levels are increased in the retina of rats with Ang II-stimulated hypertension.
Title: Plasma kallikrein mediates angiotensin II type 1 receptor-stimulated retinal vascular permeability.
Klk7 rat gene was expressed at high levels in the submandibular glands of transgenic mice.
Title: The transcriptional regulatory strategy of the rat tissue kallikrein gene family.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Arb51 (e-PCR)
- UniSTS:240143

D1Mco28 (e-PCR)
- UniSTS:240507

D1Wox18 (e-PCR)
- UniSTS:117945

d1mit20 (e-PCR)
- UniSTS:120258

RH94541 (e-PCR)
- UniSTS:119789

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein 1

Names: Kallikrein 1, renal/pancreas/salivary; esterase B; glandular kallikrein-7, submandibular/renal; kallikrein 1-like peptidase; kallikrein 1-related peptidase C7; kallikrein 5; kallikrein 7; kallikrein a3; kallikrein-related protein K1; proteinase A; renal kallikrein; tissue kallikrein

NP_036725.2

EC 3.4.21.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.