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    Folr1 folate receptor alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Folr1provided by RGD
    Official Full Name
    folate receptor alphaprovided by RGD
    Primary source
    RGD:71032
    See related
    EnsemblRapid:ENSRNOG00000019902 AllianceGenome:RGD:71032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fbp1
    Summary
    Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Predicted to be involved in several processes, including circulatory system development; nervous system development; and regulation of signal transduction. Predicted to act upstream of or within folic acid metabolic process. Located in brush border membrane. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1929.3) and Testes (RPKM 104.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Folr1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165631462..165650430, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156219460..156238436, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (166934457..166945864, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene putative uncharacterized protein Neighboring gene folate receptor beta Neighboring gene ribosomal protein L12, pseudogene 3 Neighboring gene anaphase promoting complex subunit 15 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exposure to Folate Receptor Alpha Antibodies during Gestation and Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study. Sequeira JM, et al. PLoS One, 2016. PMID 27011008, Free PMC Article
    2. Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome. Pravenec M, et al. Hypertension, 2016 Feb. PMID 26667416
    3. Internalization and intracellular transport of folate-binding protein in rat kidney proximal tubule. Birn H, et al. Am J Physiol, 1993 Feb. PMID 8447363
    4. Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules. da Costa M, et al. Am J Physiol Cell Physiol, 2000 Apr. PMID 10751329
    5. Coding sequence, genomic organization and expression of a folate binding protein gene in the rat. Sadasivan E, et al. Gene, 2000 Aug 22. PMID 10974553

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
      Title: A Paternal Methylation Error in the Congenital Hydrocephalic Texas (H-Tx) Rat Is Partially Rescued with Natural Folate Supplements.
    2. Folr1 plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat.
      Title: Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats.
    3. These observations have implications in the pathology of FRa-autoantibodies associated with neural tube defect pregnancy, preterm birth and neurodevelopmental disorders including autism
      Title: Exposure to Folate Receptor Alpha Antibodies during Gestation and Weaning Leads to Severe Behavioral Deficits in Rats: A Pilot Study.
    4. inherited variation in the expression of Folr1 in the kidney influences the development of the metabolic syndrome
      Title: Genetic Variation in Renal Expression of Folate Receptor 1 (Folr1) Gene Predisposes Spontaneously Hypertensive Rats to Metabolic Syndrome.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables folic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables folic acid receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to folic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within folic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in folic acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart looping ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest cell migration involved in heart formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pharyngeal arch artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to axon injury ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm-egg recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    folate receptor alpha
    Names
    folate binding protein 1
    folate receptor 1 (adult)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133527.2 → NP_598211.2  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      FM059473, FM060472, JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I6X2, G3V8M6, Q9JL02
      Related
      ENSRNOP00000026962.3, ENSRNOT00000026962.6
      Conserved Domains (1) summary
      pfam03024
      Location:34 → 209
      Folate_rec; Folate receptor family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      165631462..165650430 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085707.2 → XP_038941635.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      A6I6X2, G3V8M6, Q9JL02
      Conserved Domains (1) summary
      pfam03024
      Location:34 → 209
      Folate_rec; Folate receptor family

    2. XM_039085665.2 → XP_038941593.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      A6I6X2, G3V8M6, Q9JL02
      Conserved Domains (1) summary
      pfam03024
      Location:34 → 209
      Folate_rec; Folate receptor family

    3. XM_039085757.2 → XP_038941685.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      A6I6X2, G3V8M6, Q9JL02
      Conserved Domains (1) summary
      pfam03024
      Location:34 → 209
      Folate_rec; Folate receptor family

    4. XM_063273361.1 → XP_063129431.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      A6I6X2, G3V8M6, Q9JL02

    5. XM_063273405.1 → XP_063129475.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      A6I6X2, G3V8M6, Q9JL02

    6. XM_017588710.3 → XP_017444199.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      A6I6X2, G3V8M6, Q9JL02
      Conserved Domains (1) summary
      pfam03024
      Location:34 → 209
      Folate_rec; Folate receptor family

    7. XM_017588711.3 → XP_017444200.1  folate receptor alpha isoform X1

      UniProtKB/TrEMBL
      A6I6X2, G3V8M6, Q9JL02
      Conserved Domains (1) summary
      pfam03024
      Location:34 → 209
      Folate_rec; Folate receptor family

    8. XM_006229842.5 → XP_006229904.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006229904.1

      UniProtKB/TrEMBL
      A6I6X2, G3V8M6, Q9JL02
      Conserved Domains (1) summary
      pfam03024
      Location:34 → 209
      Folate_rec; Folate receptor family

    9. XM_063273293.1 → XP_063129363.1  folate receptor alpha isoform X2

      UniProtKB/TrEMBL
      Q9JL02
    Nucleotide Protein Strain
    Heading Accession and Version

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