Eif3h eukaryotic translation initiation factor 3, subunit H [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Eif3hprovided by RGD
Full Name: eukaryotic translation initiation factor 3, subunit Hprovided by RGD
Primary source: RGD:735178
See related: EnsemblRapid:ENSRNOG00000004252 AllianceGenome:RGD:735178
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Eif3s3; eIF-3-gamma
Summary: Predicted to enable metal-dependent deubiquitinase activity. Predicted to contribute to translation initiation factor activity. Predicted to be involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process and translational initiation. Predicted to be part of eukaryotic 43S preinitiation complex and eukaryotic translation initiation factor 3 complex, eIF3m. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 700.0), Spleen (RPKM 651.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q31

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (84980891..85064284, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (83091037..83174451, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (10151732..10236677)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal-dependent deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables metal-dependent deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info
contributes_to translation initiation factor activity	ISO Inferred from Sequence Orthology more info
contributes_to translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in formation of cytoplasmic translation initiation complex	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of eukaryotic 43S preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic 43S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic 48S preinitiation complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 3 complex	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex	ISO Inferred from Sequence Orthology more info
part_of eukaryotic translation initiation factor 3 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 3 complex, eIF3m	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 3 subunit H

Names: eIF3 p40 subunit; eukaryotic translation initiation factor 3 subunit 3; eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198751.4 → NP_942046.1 eukaryotic translation initiation factor 3 subunit H

See identical proteins and their annotated locations for NP_942046.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

Q6P9U8

UniProtKB/TrEMBL

A0A8I5ZP79

Related

ENSRNOP00000058501.5, ENSRNOT00000061786.6

Conserved Domains (1) summary

cd08065
Location:37 → 300

MPN_eIF3h; Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in eIF2h