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    Rras RAS related [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361568, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rrasprovided by RGD
    Official Full Name
    RAS relatedprovided by RGD
    Primary source
    RGD:1311443
    See related
    EnsemblRapid:ENSRNOG00000037247 AllianceGenome:RGD:1311443
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p23
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in several processes, including face morphogenesis; positive regulation of endothelial cell-matrix adhesion via fibronectin; and regulation of intracellular signal transduction. Predicted to act upstream of or within negative regulation of Schwann cell migration. Predicted to be active in plasma membrane. Orthologous to human RRAS (RAS related). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 118.3), Heart (RPKM 87.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rras in Genome Data Viewer
    Location:
    1q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104637061..104640841)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95500582..95504362)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101012822..101016720)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene Bcl2 like 12 Neighboring gene interferon regulatory factor 3 Neighboring gene SR-related CTD-associated factor 1 Neighboring gene proline rich 12 Neighboring gene proline rich and Gla domain 2 Neighboring gene nitric oxide synthase interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis. Flex E, et al. Hum Mol Genet, 2014 Aug 15. PMID 24705357, Free PMC Article
    2. Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. Carta C, et al. Am J Hum Genet, 2006 Jul. PMID 16773572, Free PMC Article
    3. The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling. Sandri C, et al. Cell Res, 2012 Oct. PMID 22825554, Free PMC Article
    4. The Semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Oinuma I, et al. Science, 2004 Aug 6. PMID 15297673
    5. Role of TC21/R-Ras2 in enhanced migration of neurofibromin-deficient Schwann cells. Huang Y, et al. Oncogene, 2004 Jan 15. PMID 14724565, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of Schwann cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of Schwann cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vasculogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein R-Ras
    Names
    Harvey rat sarcoma oncogene, subgroup R
    Harvey rat sarcoma virus oncogene, subgroup R
    RAS-related viral oncoprotein
    Ras-related protein R-RAS (P23)
    related RAS viral (r-ras) oncogene homolog
    NP_001101951.1
    XP_038938093.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108481.1 → NP_001101951.1  ras-related protein R-Ras

      See identical proteins and their annotated locations for NP_001101951.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/Swiss-Prot
      D3Z8L7
      Related
      ENSRNOP00000027809.5, ENSRNOT00000027809.9
      Conserved Domains (2) summary
      smart00010
      Location:42 → 193
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
      cl21455
      Location:28 → 191
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104637061..104640841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082165.2 → XP_038938093.1  ras-related protein R-Ras isoform X1

      Conserved Domains (1) summary
      smart00010
      Location:1 → 101
      small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z8L7.1 GenPept UniProtKB/Swiss-Prot:D3Z8L7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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