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    Cdhr2 cadherin-related family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291002, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdhr2provided by RGD
    Official Full Name
    cadherin-related family member 2provided by RGD
    Primary source
    RGD:1560576
    See related
    EnsemblRapid:ENSRNOG00000017917 AllianceGenome:RGD:1560576
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pcdh24; RGD1560576
    Summary
    Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; intermicrovillar adhesion; and negative regulation of cell growth involved in contact inhibition. Predicted to be located in apical plasma membrane; brush border membrane; and microvillus membrane. Predicted to be active in plasma membrane. Orthologous to human CDHR2 (cadherin related family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 180.2), Brain (RPKM 28.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdhr2 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9881979..9917698, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9876853..9913356, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10415044..10450589, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E family member 1B Neighboring gene synuclein, beta Neighboring gene G protein-regulated inducer of neurite outgrowth 1 Neighboring gene ring finger protein 44 Neighboring gene Fas associated factor family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. Okazaki N, et al. Carcinogenesis, 2002 Jul. PMID 12117771
    2. Proteomic analysis of the enterocyte brush border. McConnell RE, et al. Am J Physiol Gastrointest Liver Physiol, 2011 May. PMID 21330445, Free PMC Article
    3. Intestinal brush border assembly driven by protocadherin-based intermicrovillar adhesion. Crawley SW, et al. Cell, 2014 Apr 10. PMID 24725409, Free PMC Article
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in brush border assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intermicrovillar adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth involved in contact inhibition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microvillus length ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cadherin-related family member 2
    Names
    protocadherin 24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427596.1 → NP_001414525.1  cadherin-related family member 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6KAX4, D3ZAN2
      Related
      ENSRNOP00000024151.5, ENSRNOT00000024151.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9881979..9917698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096513.2 → XP_038952441.1  cadherin-related family member 2 isoform X2

      Conserved Domains (1) summary
      cd11304
      Location:95 → 192
      Cadherin_repeat; Cadherin tandem repeat domain

    2. XM_039096512.2 → XP_038952440.1  cadherin-related family member 2 isoform X1

      UniProtKB/TrEMBL
      A6KAX4
      Conserved Domains (1) summary
      cd11304
      Location:338 → 435
      Cadherin_repeat; Cadherin tandem repeat domain
    Nucleotide Protein Strain
    Heading Accession and Version

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