C1qtnf4 C1q and TNF related 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C1qtnf4provided by RGD
Official Full Name: C1q and TNF related 4provided by RGD
Primary source: RGD:1311006
See related: EnsemblRapid:ENSRNOG00000081381 AllianceGenome:RGD:1311006
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in positive regulation of cytokine production and positive regulation of signal transduction. Predicted to be active in extracellular space. Orthologous to human C1QTNF4 (C1q and TNF related 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 240.9) and Kidney (RPKM 15.8) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (97310220..97328818)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (76854368..76872991)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (79713580..79718018)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CTRP4 can significantly inhibit the activation of caspase-1/IL-1beta inflammatory pathway, and suppress the pyroptosis of trophoblasts derived from rats with preeclampsia.
Title: [C1q and tumor necrosis factor related protein 4 (CTRP4) suppresses caspase-1/IL-1β inflammatory pathway in trophoblasts of rat models with preeclampsia].
These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance.
Title: C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight.

Submit: New GeneRIF Correction

General gene information

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Markers

d3arb19 (e-PCR)
- UniSTS:121768

RH138557 (e-PCR)
- UniSTS:220644

RH144199 (e-PCR)
- UniSTS:233445

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reduction of food intake in response to dietary excess	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q tumor necrosis factor-related protein 4

Names: C1q and tumor necrosis factor related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107745.1 → NP_001101215.1 complement C1q tumor necrosis factor-related protein 4 precursor

See identical proteins and their annotated locations for NP_001101215.1

Status: PROVISIONAL

Source sequence(s)

CH473949

UniProtKB/TrEMBL

A0A8I6ACA8, A6HN85, B5DF52

Related

ENSRNOP00000089610.1, ENSRNOT00000099320.2

Conserved Domains (1) summary

pfam00386
Location:30 → 155

C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

97310220..97328818

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104895.2 → XP_038960823.1 complement C1q tumor necrosis factor-related protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I6ACA8, A6HN85, B5DF52

Conserved Domains (1) summary

pfam00386
Location:30 → 155

C1q; C1q domain
XM_039104894.2 → XP_038960822.1 complement C1q tumor necrosis factor-related protein 4 isoform X1

UniProtKB/TrEMBL

A0A8I6ACA8, A6HN85, B5DF52

Conserved Domains (1) summary

pfam00386
Location:30 → 155

C1q; C1q domain