Repin1 replication initiator 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Repin1provided by RGD
Full Name: replication initiator 1provided by RGD
Primary source: RGD:1549707
See related: EnsemblRapid:ENSRNOG00000008239 AllianceGenome:RGD:1549707
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ap4; Ap-4
Summary: Predicted to enable chromatin insulator sequence binding activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of fatty acid transport and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of D-glucose import. Predicted to be located in cytosolic ribosome; lipid droplet; and nucleus. Predicted to be active in chromosome. Orthologous to human REPIN1 (replication initiator 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 73.8), Kidney (RPKM 59.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (78879910..78885143)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (77548724..77554242)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (78232454..78237498)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data on gene expression in epididymal/subcutaneous adipose tissue suggest that Repin1 is more highly expressed in a congenic rat model of metabolic syndrome; thus, Repin1 may affect development of facets of metabolic syndrome.
Title: Gene expression profiling supports the role of Repin1 in the pathophysiology of metabolic syndrome.
The functional unknown gene, Repin1, may be a novel candidate gene for the development of facets of the metabolic syndrome.
Title: Triplet repeat in the Repin1 3'-untranslated region on rat chromosome 4 correlates with facets of the metabolic syndrome.
It is concluded that the triplet repeat expansion in 3'-UTR of Repin1 leads to metabolic disorders as found in hHTG and WOKW rats and that Repin1 could be a novel candidate gene in the development of metabolic disorders.
Title: Triplet repeat in the Repin1 3'-untranslated region on rat chromosome 4 correlates with facets of the metabolic syndrome.
findings show that glutamate receptor delta2 interacted directly with AP-4; results suggest a potential involvement of AP-4 in the trafficking of delta2 in the brain.
Title: Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin insulator sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of fatty acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA-binding protein REPIN1; replication initiator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005893.4 → NP_001005893.1 DNA-binding protein REPIN1 isoform 5

See identical proteins and their annotated locations for NP_001005893.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q68H95

Conserved Domains (3) summary

COG5048
Location:250 → 521

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:442 → 462

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:454 → 479

zf-H2C2_2; Zinc-finger double domain
NM_001398903.2 → NP_001385832.1 DNA-binding protein REPIN1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

Conserved Domains (2) summary

COG5048
Location:309 → 580

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:501 → 521

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001398904.2 → NP_001385833.1 DNA-binding protein REPIN1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

Conserved Domains (2) summary

COG5048
Location:308 → 579

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:500 → 520

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001398905.2 → NP_001385834.1 DNA-binding protein REPIN1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0H2UHG5

Related

ENSRNOP00000088288.2, ENSRNOT00000117289.2

Conserved Domains (2) summary

COG5048
Location:306 → 577

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:498 → 518

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001398906.2 → NP_001385835.1 DNA-binding protein REPIN1 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

78879910..78885143

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236427.5 → XP_006236489.1 replication initiator 1 isoform X1

UniProtKB/TrEMBL

A0A0H2UHG5

Conserved Domains (2) summary

COG5048
Location:306 → 577

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:498 → 518

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_063286436.1 → XP_063142506.1 replication initiator 1 isoform X2
XM_006236428.5 → XP_006236490.1 replication initiator 1 isoform X3

See identical proteins and their annotated locations for XP_006236490.1

UniProtKB/Swiss-Prot

Q68H95

Related

ENSRNOP00000103203.1, ENSRNOT00000146767.1

Conserved Domains (3) summary

COG5048
Location:250 → 521

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:442 → 462

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:454 → 479

zf-H2C2_2; Zinc-finger double domain