Serpinc1 serpin family C member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpinc1provided by RGD
Official Full Name: serpin family C member 1provided by RGD
Primary source: RGD:1307404
See related: EnsemblRapid:ENSRNOG00000002783 AllianceGenome:RGD:1307404
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables heparin binding activity and serine-type endopeptidase inhibitor activity. Involved in acute inflammatory response to antigenic stimulus; lactation; and response to nutrient. Located in extracellular space. Used to study thrombosis. Biomarker of familial hyperlipidemia; nephrotic syndrome; and ovarian cancer. Human ortholog(s) of this gene implicated in antithrombin III deficiency; disseminated intravascular coagulation; intermediate coronary syndrome; thrombosis; and toxic shock syndrome. Orthologous to human SERPINC1 (serpin family C member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 10280.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (75790558..75804826)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (73257208..73271476)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (78806107..78820375)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Antithrombin III prevents progression of chronic kidney disease following experimental ischaemic-reperfusion injury.
Title: Antithrombin III prevents progression of chronic kidney disease following experimental ischaemic-reperfusion injury.
SerpinC1 insufficiency in increasing the severity of renal ischemia/reperfusion injury.
Title: Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury.
antithrombin diminishes pulmonary endothelial damage induced by crush injury
Title: The effect of antithrombin on pulmonary endothelial damage induced by crush injury.
AT might reduce the I/R-induced liver injury by increasing the production of PGI2 and PGE2 through activation of COX-1. (antithrombin III)
Title: Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1.

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General gene information

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Markers

Serpinc1 (e-PCR), detects polymorphism
- UniSTS:525942

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acute inflammatory response to antigenic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: antithrombin-III

Names: antithrombin III; serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin peptidase inhibitor, clade C (antithrombin), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012027.1 → NP_001012027.1 antithrombin-III precursor

See identical proteins and their annotated locations for NP_001012027.1

Status: PROVISIONAL

Source sequence(s)

BC088467

UniProtKB/TrEMBL

F7EY53, Q5M7T5

Related

ENSRNOP00000077314.1, ENSRNOT00000115784.2

Conserved Domains (1) summary

cd02045
Location:80 → 459

antithrombin-III_like; Antithrombin is a serine proteinase inhibitor (serpin) which controls the process of coagulation. It is the most important anticoagulant molecule in mammalian circulation systems, controlled by its interaction with the co-factor, heparin, which ...