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    Caap1 caspase activity and apoptosis inhibitor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500501, updated on 9-Dec-2024

    Summary

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    Symbol
    Caap1provided by RGD
    Full Name
    caspase activity and apoptosis inhibitor 1provided by RGD
    Primary source
    RGD:1560251
    See related
    EnsemblRapid:ENSRNOG00000007299 AllianceGenome:RGD:1560251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Orthologous to human CAAP1 (caspase activity and apoptosis inhibitor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 65.8), Spleen (RPKM 59.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Caap1 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (114428991..114530047, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (109313253..109414323, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (113479416..113532961, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102919 Neighboring gene large ribosomal subunit protein uL2-like Neighboring gene uncharacterized LOC120102920 Neighboring gene phospholipase A2, activating protein Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. Zhang Y, et al. PLoS One, 2011. PMID 21980415, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC125002

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    caspase activity and apoptosis inhibitor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034154.4 → NP_001029326.2  caspase activity and apoptosis inhibitor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    2. NM_001415955.1 → NP_001402884.1  caspase activity and apoptosis inhibitor 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JRG1, A6JRG2, G3V6Y7, Q3KR90
      Related
      ENSRNOP00000010173.5, ENSRNOT00000010173.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      114428991..114530047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288234.1 → XP_063144304.1  caspase activity and apoptosis inhibitor 1 isoform X1

    RNA

    1. XR_005504518.2 RNA Sequence

    2. XR_010066459.1 RNA Sequence

    3. XR_010066458.1 RNA Sequence

    4. XR_005504515.2 RNA Sequence

    5. XR_010066455.1 RNA Sequence

    6. XR_010066456.1 RNA Sequence

    7. XR_010066454.1 RNA Sequence

    8. XR_005504514.2 RNA Sequence

    9. XR_010066453.1 RNA Sequence

    10. XR_010066457.1 RNA Sequence

    11. XR_010066452.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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