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    Btnl3 butyrophilin-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 407781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Btnl3provided by RGD
    Official Full Name
    butyrophilin-like 3provided by RGD
    Primary source
    RGD:1303262
    See related
    EnsemblRapid:ENSRNOG00000039396 AllianceGenome:RGD:1303262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Btnl1
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 2.2), Testes (RPKM 1.6) and 5 other tissues See more
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    Genomic context

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    See Btnl3 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4475984..4490955, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4474056..4489024, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4156858..4171887)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene butyrophilin, subfamily 3, member A2 Neighboring gene uncharacterized LOC134483778 Neighboring gene testis expressed basic protein 1 Neighboring gene uncharacterized LOC108349035 Neighboring gene butyrophilin-like 2 Neighboring gene RT1 class II, locus Da

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extrathymic T cell selection IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    butyrophilin-like protein 1
    Names
    butyrophilin-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002803.2 → NP_001002803.2  butyrophilin-like protein 1 isoform 2

      Status: PROVISIONAL

      Source sequence(s)
      BX883043
      UniProtKB/TrEMBL
      A0A8I6B1V5, F7FDE0
      Related
      ENSRNOP00000098181.2, ENSRNOT00000120528.2
      Conserved Domains (4) summary
      cd05713
      Location:46 → 144
      Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
      smart00410
      Location:39 → 144
      IG_like; Immunoglobulin like
      pfam03879
      Location:271 → 311
      Cgr1; Cgr1 family
      cl02614
      Location:377 → 492
      SPRY; SPRY domain

    2. NM_001434731.1 → NP_001421660.1  butyrophilin-like protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6B1V5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4475984..4490955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279384.1 → XP_063135454.1  butyrophilin-like protein 1 isoform X2

    2. XM_017601723.3 → XP_017457212.1  butyrophilin-like protein 1 isoform X1

      Related
      ENSRNOP00000069906.3, ENSRNOT00000081236.4

    3. XM_063279385.1 → XP_063135455.1  butyrophilin-like protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JWJ6
    Nucleotide Protein Strain
    Heading Accession and Version

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