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    Dcaf10 DDB1 and CUL4 associated factor 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313242, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dcaf10provided by RGD
    Official Full Name
    DDB1 and CUL4 associated factor 10provided by RGD
    Primary source
    RGD:1304730
    See related
    EnsemblRapid:ENSRNOG00000011655 AllianceGenome:RGD:1304730
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr32; RGD1304730
    Summary
    Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to human DCAF10 (DDB1 and CUL4 associated factor 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 94.2), Lung (RPKM 68.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcaf10 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (64402307..64442839)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (59607795..59647209)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (60900390..60937547)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486935 Neighboring gene exosome component 3 Neighboring gene phosphoglycerate mutase 1, pseudogene 8 Neighboring gene DDB1 and CUL4 associated factor 10 like Neighboring gene solute carrier family 25, member 51 Neighboring gene SH2 domain containing adaptor protein B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 10
    Names
    WD repeat domain 32

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107935.1 → NP_001101405.1  DDB1- and CUL4-associated factor 10

      See identical proteins and their annotated locations for NP_001101405.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473962
      UniProtKB/TrEMBL
      A6IJ94, D4A8G6
      Related
      ENSRNOP00000016384.5, ENSRNOT00000016384.7
      Conserved Domains (3) summary
      smart00320
      Location:521 → 559
      WD40; WD40 repeats
      sd00039
      Location:176 → 211
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:168 → 323
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      64402307..64442839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238066.5 → XP_006238128.1  DDB1- and CUL4-associated factor 10 isoform X1

      Conserved Domains (3) summary
      smart00320
      Location:455 → 493
      WD40; WD40 repeats
      COG2319
      Location:173 → 493
      WD40; WD40 repeat [General function prediction only]
      cl02567
      Location:168 → 227
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_010066397.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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