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    Cyp2j10 cytochrome P450, family 2, subfamily j, polypeptide 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313373, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyp2j10provided by RGD
    Official Full Name
    cytochrome P450, family 2, subfamily j, polypeptide 10provided by RGD
    Primary source
    RGD:1563215
    See related
    EnsemblRapid:ENSRNOG00000042224 AllianceGenome:RGD:1563215
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563215
    Summary
    Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension; myocardial infarction; pulmonary hypertension; renal fibrosis; and renal hypertension. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 46.1), Liver (RPKM 28.1) and 8 other tissues See more
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    Genomic context

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    See Cyp2j10 in Genome Data Viewer
    Location:
    5q33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (116076012..116110914, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (110960319..110995220, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (115067847..115101961, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102925 Neighboring gene hook microtubule-tethering protein 1 Neighboring gene cytochrome P450 2J3-like Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 16, pseudogene 1 Neighboring gene uncharacterized LOC134479009 Neighboring gene cytochrome P450, family 2, subfamily j, polypeptide 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188856

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 2, subfamily j, polypeptide 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134980.2 → NP_001128452.2  cytochrome P450, family 2, subfamily j, polypeptide 10

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      B5DEP8, E9PSJ0
      Related
      ENSRNOP00000046904.6, ENSRNOT00000045686.7
      Conserved Domains (1) summary
      cl41757
      Location:75 → 496
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      116076012..116110914 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109899.2 → XP_038965827.1  cytochrome P450, family 2, subfamily j, polypeptide 10 isoform X1

      UniProtKB/TrEMBL
      A6JRI7
      Conserved Domains (1) summary
      cl41757
      Location:75 → 398
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    2. XM_039109900.2 → XP_038965828.1  cytochrome P450, family 2, subfamily j, polypeptide 10 isoform X3

      Conserved Domains (2) summary
      cl12078
      Location:18 → 118
      p450; Cytochrome P450
      cl41757
      Location:75 → 289
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    3. XM_063287640.1 → XP_063143710.1  cytochrome P450, family 2, subfamily j, polypeptide 10 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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