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    Ubox5 U-box domain containing 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296161, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ubox5provided by RGD
    Official Full Name
    U-box domain containing 5provided by RGD
    Primary source
    RGD:1305440
    See related
    EnsemblRapid:ENSRNOG00000021230 AllianceGenome:RGD:1305440
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305440
    Summary
    Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-ubiquitin ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in focal adhesion and nuclear body. Predicted to be active in nucleus. Orthologous to human UBOX5 (U-box domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 45.6), Thymus (RPKM 38.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ubox5 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138259311..138300807, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117806212..117847711, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123130249..123171875, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene oxytocin/neurophysin I prepropeptide Neighboring gene arginine vasopressin Neighboring gene FAST kinase domains 5 Neighboring gene leucine zipper tumor suppressor family member 3 Neighboring gene DDRGK domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. Pringa E, et al. J Biol Chem, 2001 Jun 1. PMID 11274149
    2. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 37
    NP_001029169.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033997.1 → NP_001029169.1  RING finger protein 37

      See identical proteins and their annotated locations for NP_001029169.1

      Status: PROVISIONAL

      Source sequence(s)
      BC101912
      UniProtKB/TrEMBL
      A0A8I5ZXT6, Q3T1H9
      Related
      ENSRNOP00000028834.5, ENSRNOT00000028834.6
      Conserved Domains (2) summary
      cd16537
      Location:479 → 525
      RING-HC_RNF37; RING finger, HC subclass, found in RING finger protein 37 (RNF37)
      cd16660
      Location:260 → 312
      RING-Ubox_RNF37; U-box domain, a modified RING finger, found in RING finger protein 37 (RNF37)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138259311..138300807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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