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    Ap3d1 adaptor related protein complex 3 subunit delta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314633, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ap3d1provided by RGD
    Official Full Name
    adaptor related protein complex 3 subunit delta 1provided by RGD
    Primary source
    RGD:1308659
    See related
    EnsemblRapid:ENSRNOG00000018977 AllianceGenome:RGD:1308659
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ap3d
    Summary
    Involved in synaptic vesicle budding from endosome. Predicted to be located in axon. Predicted to be part of AP-3 adaptor complex. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and terminal bouton. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Orthologous to human AP3D1 (adaptor related protein complex 3 subunit delta 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 201.8), Brain (RPKM 185.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ap3d1 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9620909..9656350)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8970249..9005651)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11838639..11873992)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing J1 Neighboring gene DOT1 like histone lysine methyltransferase Neighboring gene uncharacterized LOC134479808 Neighboring gene uncharacterized LOC120093774 Neighboring gene IZUMO family member 4 Neighboring gene MOB kinase activator 3A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi to vacuole transport  
    involved_in anterograde axonal transport  
    involved_in anterograde synaptic vesicle transport  
    involved_in anterograde synaptic vesicle transport  
    acts_upstream_of_or_within antigen processing and presentation  
    acts_upstream_of_or_within antigen processing and presentation, exogenous lipid antigen via MHC class Ib  
    involved_in endosome to melanosome transport  
    acts_upstream_of_or_within intracellular protein transport  
    involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome  
    involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome  
    acts_upstream_of_or_within positive regulation of NK T cell differentiation  
    acts_upstream_of_positive_effect positive regulation of transcription by RNA polymerase II  
    involved_in protein localization to membrane  
    acts_upstream_of_or_within protein localization to organelle  
    acts_upstream_of_or_within protein targeting  
    involved_in protein targeting to vacuole  
    involved_in synaptic vesicle budding from endosome  
    involved_in synaptic vesicle budding from endosome PubMed 
    involved_in synaptic vesicle budding from endosome PubMed 
    involved_in synaptic vesicle budding from endosome  
    involved_in synaptic vesicle membrane organization  
    acts_upstream_of_or_within synaptic vesicle membrane organization  
    involved_in vesicle-mediated transport in synapse  
    involved_in zinc ion import into lysosome  
    Component Evidence Code Pubs
    part_of AP-3 adaptor complex  
    located_in axon  
    located_in axon cytoplasm  
    is_active_in endosome membrane  
    located_in endosome membrane  
    is_active_in glutamatergic synapse  
    is_active_in postsynapse  
    is_active_in presynapse  
    is_active_in presynaptic endosome  
    is_active_in presynaptic endosome  
    is_active_in terminal bouton  
    located_in terminal bouton  

    General protein information

    Preferred Names
    AP-3 complex subunit delta-1
    Names
    adaptor-related protein complex 3, delta 1 subunit
    adaptor-related protein complex 3, delta subunit

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100719.1NP_001094189.1  AP-3 complex subunit delta-1

      See identical proteins and their annotated locations for NP_001094189.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169097
      UniProtKB/TrEMBL
      A0A8I6AM24, B5DFK6, F7F0K5
      Related
      ENSRNOP00000025878.5, ENSRNOT00000025878.7
      Conserved Domains (4) summary
      pfam01602
      Location:32581
      Adaptin_N; Adaptin N terminal region
      pfam06375
      Location:661803
      BLVR; Bovine leukaemia virus receptor (BLVR)
      pfam12717
      Location:155265
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:151172
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9620909..9656350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263422.1XP_063119492.1  AP-3 complex subunit delta-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AM24
    2. XM_039079008.2XP_038934936.1  AP-3 complex subunit delta-1 isoform X3

      UniProtKB/TrEMBL
      A6K8H3
      Conserved Domains (3) summary
      sd00044
      Location:151172
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:32581
      Adaptin_N; Adaptin N terminal region
      pfam06375
      Location:661803
      AP3D1; AP-3 complex subunit delta-1
    3. XM_063263423.1XP_063119493.1  AP-3 complex subunit delta-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AM24
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