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    Gpc1 glypican 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58920, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpc1provided by RGD
    Official Full Name
    glypican 1provided by RGD
    Primary source
    RGD:61853
    See related
    EnsemblRapid:ENSRNOG00000049437 AllianceGenome:RGD:61853
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    HSPGM12; HSPG M12
    Summary
    Enables collagen V binding activity. Involved in Schwann cell differentiation and myelin assembly. Located in neuronal cell body. Orthologous to human GPC1 (glypican 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 904.5), Muscle (RPKM 537.7) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Gpc1 in Genome Data Viewer
    Location:
    9q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (100843645..100871458)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (93396234..93424047)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (99998275..100026818)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480418 Neighboring gene uncharacterized LOC134480417 Neighboring gene uncharacterized LOC134480611 Neighboring gene microRNA 149 Neighboring gene uncharacterized LOC120094747 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene arginyl aminopeptidase like 1 Neighboring gene dual specificity phosphatase 28

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen V binding PubMed 
    enables copper ion binding  
    enables copper ion binding  
    enables copper ion binding  
    enables fibroblast growth factor binding  
    enables fibroblast growth factor binding  
    enables fibroblast growth factor binding  
    enables fibroblast growth factor binding  
    enables laminin binding  
    enables laminin binding  
    enables laminin binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in Schwann cell differentiation PubMed 
    involved_in biological_process  
    involved_in cell migration  
    involved_in heparan sulfate proteoglycan catabolic process  
    involved_in heparan sulfate proteoglycan catabolic process  
    involved_in heparan sulfate proteoglycan catabolic process  
    involved_in myelin assembly PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway  
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway  
    involved_in positive regulation of skeletal muscle cell differentiation  
    involved_in positive regulation of skeletal muscle cell differentiation  
    involved_in positive regulation of skeletal muscle cell differentiation  
    involved_in regulation of protein localization to membrane  
    Component Evidence Code Pubs
    is_active_in cell surface  
    located_in collagen-containing extracellular matrix  
    located_in cytosol  
    located_in cytosol  
    located_in endosome  
    located_in extracellular matrix  
    located_in extracellular matrix  
    located_in extracellular region  
    located_in membrane raft  
    located_in membrane raft  
    located_in membrane raft  
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in side of membrane  
    is_active_in synapse  
    located_in synapse  
    is_active_in synapse  

    General protein information

    Preferred Names
    glypican-1
    Names
    GPI-anchored cell surface heparan sulfate proteoglycan

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030828.2NP_110455.2  glypican-1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P35053
      UniProtKB/TrEMBL
      Q6P7Q2
      Related
      ENSRNOP00000066597.1, ENSRNOT00000074395.3
      Conserved Domains (1) summary
      pfam01153
      Location:22539
      Glypican

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      100843645..100871458
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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