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    Tnf tumor necrosis factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24835, updated on 27-Dec-2024

    Summary

    Symbol
    Tnfprovided by RGD
    Full Name
    tumor necrosis factorprovided by RGD
    Primary source
    RGD:3876
    See related
    EnsemblRapid:ENSRNOG00000070745 AllianceGenome:RGD:3876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tnfa; RATTNF; TNF-alpha
    Summary
    Enables tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of transport; positive regulation of cell communication; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within positive regulation of interleukin-6 production. Located in external side of plasma membrane; extracellular space; and neuronal cell body. Is active in extracellular region. Used to study several diseases, including cerebrovascular disease (multiple); liver disease (multiple); peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); congestive heart failure (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); liver disease (multiple); lung disease (multiple); and skin disease (multiple). Orthologous to human TNF (tumor necrosis factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 30.7), Spleen (RPKM 26.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tnf in Genome Data Viewer
    Location:
    20p12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3626685..3629303)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3622011..3624629)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5189382..5192000, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit G2 Neighboring gene NFKB inhibitor like 1 Neighboring gene lymphotoxin alpha Neighboring gene lymphotoxin beta Neighboring gene leukocyte specific transcript 1 Neighboring gene natural cytotoxicity triggering receptor 3

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC124630

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity  
    enables cytokine activity  
    enables cytokine activity PubMed 
    enables death receptor agonist activity  
    enables identical protein binding  
    enables protease binding  
    enables receptor ligand activity  
    enables transcription cis-regulatory region binding  
    enables tumor necrosis factor receptor binding PubMed 
    enables tumor necrosis factor receptor binding  
    enables tumor necrosis factor receptor binding PubMed 
    enables tumor necrosis factor receptor binding  
    Items 1 - 25 of 245
    Process Evidence Code Pubs
    acts_upstream_of JNK cascade  
    acts_upstream_of_or_within JNK cascade  
    acts_upstream_of_or_within animal organ morphogenesis  
    involved_in antiviral innate immune response  
    acts_upstream_of_or_within apoptotic signaling pathway  
    involved_in calcium-mediated signaling PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT PubMed 
    acts_upstream_of_or_within cellular extravasation  
    acts_upstream_of_or_within cellular response to amino acid stimulus  
    involved_in cellular response to amyloid-beta PubMed 
    involved_in cellular response to ionizing radiation  
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in cellular response to lipopolysaccharide PubMed 
    acts_upstream_of_or_within cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to molecule of bacterial origin PubMed 
    involved_in cellular response to nicotine  
    involved_in cellular response to retinoic acid PubMed 
    involved_in cellular response to toxic substance PubMed 
    involved_in cellular response to type II interferon PubMed 
    involved_in cellular response to type II interferon  
    involved_in chronic inflammatory response to antigenic stimulus  
    involved_in circadian rhythm PubMed 
    acts_upstream_of_or_within defense response  
    acts_upstream_of_or_within defense response to Gram-positive bacterium  
    acts_upstream_of_or_within defense response to bacterium  
    involved_in detection of mechanical stimulus involved in sensory perception of pain PubMed 
    involved_in embryonic digestive tract development  
    involved_in endothelial cell apoptotic process  
    acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis  
    acts_upstream_of_or_within extracellular matrix organization  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway  
    involved_in extrinsic apoptotic signaling pathway  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    acts_upstream_of_or_within glucose metabolic process  
    acts_upstream_of_or_within humoral immune response  
    involved_in immune response  
    involved_in immune response  
    acts_upstream_of_or_within inflammatory response  
    involved_in inflammatory response  
    involved_in inflammatory response to wounding  
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage  
    acts_upstream_of_or_within leukocyte migration  
    involved_in leukocyte migration involved in inflammatory response PubMed 
    involved_in leukocyte tethering or rolling  
    involved_in liver regeneration PubMed 
    involved_in macrophage activation involved in immune response  
    involved_in microglial cell activation  
    involved_in necroptotic signaling pathway  
    acts_upstream_of_or_within necroptotic signaling pathway  
    involved_in necroptotic signaling pathway  
    involved_in necroptotic signaling pathway  
    involved_in negative regulation of D-glucose import PubMed 
    acts_upstream_of_or_within negative regulation of D-glucose import  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of L-glutamate import across plasma membrane PubMed 
    involved_in negative regulation of alkaline phosphatase activity  
    involved_in negative regulation of amyloid-beta clearance  
    involved_in negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic signaling pathway  
    involved_in negative regulation of bicellular tight junction assembly  
    involved_in negative regulation of bile acid secretion PubMed 
    involved_in negative regulation of blood vessel endothelial cell migration  
    involved_in negative regulation of branching involved in lung morphogenesis  
    involved_in negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of cytokine production involved in immune response  
    involved_in negative regulation of endothelial cell proliferation  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in negative regulation of fat cell differentiation PubMed 
    acts_upstream_of negative regulation of gene expression  
    acts_upstream_of_or_within negative regulation of gene expression  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of heart rate PubMed 
    involved_in negative regulation of interleukin-6 production  
    involved_in negative regulation of lipid catabolic process  
    involved_in negative regulation of mitotic cell cycle  
    involved_in negative regulation of myelination PubMed 
    acts_upstream_of_or_within negative regulation of myoblast differentiation  
    involved_in negative regulation of osteoblast differentiation  
    involved_in negative regulation of oxidative phosphorylation PubMed 
    involved_in negative regulation of protein-containing complex disassembly  
    acts_upstream_of negative regulation of signaling receptor activity  
    involved_in negative regulation of systemic arterial blood pressure PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of vascular wound healing  
    involved_in negative regulation of viral genome replication  
    acts_upstream_of_or_within osteoclast differentiation  
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of DNA biosynthetic process PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of_or_within positive regulation of I-kappaB phosphorylation  
    acts_upstream_of_or_within positive regulation of JNK cascade  
    involved_in positive regulation of JUN kinase activity  
    acts_upstream_of positive regulation of MAP kinase activity  
    involved_in positive regulation of MAP kinase activity  
    acts_upstream_of positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of action potential PubMed 
    involved_in positive regulation of amide metabolic process  
    involved_in positive regulation of amyloid-beta formation  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of blood microparticle formation  
    involved_in positive regulation of calcidiol 1-monooxygenase activity  
    acts_upstream_of_or_within positive regulation of calcineurin-NFAT signaling cascade  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production  
    involved_in positive regulation of chemokine production  
    acts_upstream_of_or_within positive regulation of chronic inflammatory response to antigenic stimulus  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of cytokine production  
    acts_upstream_of positive regulation of cytokine production involved in inflammatory response  
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response  
    involved_in positive regulation of endothelial cell apoptotic process  
    involved_in positive regulation of estradiol secretion  
    involved_in positive regulation of extrinsic apoptotic signaling pathway  
    involved_in positive regulation of extrinsic apoptotic signaling pathway PubMed 
    involved_in positive regulation of fever generation  
    involved_in positive regulation of fractalkine production PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of gene expression PubMed 
    acts_upstream_of positive regulation of gene expression  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of glial cell proliferation  
    involved_in positive regulation of hair follicle development  
    involved_in positive regulation of hepatocyte proliferation PubMed 
    involved_in positive regulation of hepatocyte proliferation PubMed 
    involved_in positive regulation of heterotypic cell-cell adhesion  
    acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin  
    involved_in positive regulation of interleukin-1 beta production  
    involved_in positive regulation of interleukin-18 production PubMed 
    acts_upstream_of positive regulation of interleukin-33 production  
    acts_upstream_of_or_within positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of interleukin-6 production PubMed 
    acts_upstream_of_or_within positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production  
    acts_upstream_of_or_within positive regulation of interleukin-8 production  
    involved_in positive regulation of interleukin-8 production  
    involved_in positive regulation of leukocyte adhesion to arterial endothelial cell  
    involved_in positive regulation of leukocyte adhesion to vascular endothelial cell  
    involved_in positive regulation of lipid metabolic process  
    involved_in positive regulation of membrane protein ectodomain proteolysis  
    acts_upstream_of positive regulation of miRNA transcription  
    involved_in positive regulation of mitotic nuclear division PubMed 
    involved_in positive regulation of neuron apoptotic process PubMed 
    involved_in positive regulation of neuron apoptotic process  
    involved_in positive regulation of neutrophil activation PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of nitric-oxide synthase activity PubMed 
    acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of osteoclast differentiation  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of podosome assembly  
    involved_in positive regulation of programmed cell death  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of protein localization to cell surface  
    involved_in positive regulation of protein localization to plasma membrane PubMed 
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein transport PubMed 
    involved_in positive regulation of protein transport  
    involved_in positive regulation of protein-containing complex assembly  
    involved_in positive regulation of protein-containing complex disassembly  
    involved_in positive regulation of smooth muscle cell proliferation  
    involved_in positive regulation of synaptic transmission PubMed 
    involved_in positive regulation of synaptic transmission  
    acts_upstream_of_or_within positive regulation of synoviocyte proliferation  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of translational initiation by iron  
    acts_upstream_of_or_within positive regulation of type II interferon production  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation  
    involved_in positive regulation of vitamin D biosynthetic process  
    involved_in protein localization to plasma membrane  
    involved_in regulation of biological quality  
    acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis  
    involved_in regulation of canonical NF-kappaB signal transduction  
    involved_in regulation of cell population proliferation PubMed 
    acts_upstream_of_or_within regulation of cell population proliferation  
    involved_in regulation of developmental process  
    involved_in regulation of endothelial cell apoptotic process  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of fat cell differentiation  
    acts_upstream_of_or_within regulation of immunoglobulin production  
    acts_upstream_of_or_within regulation of inflammatory response  
    involved_in regulation of insulin secretion  
    involved_in regulation of membrane lipid metabolic process  
    involved_in regulation of metabolic process  
    involved_in regulation of multicellular organismal process  
    acts_upstream_of_or_within regulation of osteoclast differentiation  
    acts_upstream_of_or_within regulation of protein phosphorylation  
    acts_upstream_of_or_within regulation of protein secretion  
    acts_upstream_of_or_within regulation of reactive oxygen species metabolic process  
    involved_in regulation of reactive oxygen species metabolic process  
    involved_in regulation of secretion  
    involved_in regulation of synapse organization  
    involved_in response to 3,3',5-triiodo-L-thyronine PubMed 
    involved_in response to Gram-negative bacterium PubMed 
    involved_in response to L-glutamate PubMed 
    involved_in response to activity PubMed 
    involved_in response to bacterium PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to fructose PubMed 
    involved_in response to glucocorticoid  
    involved_in response to gold nanoparticle PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to isolation stress PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to macrophage colony-stimulating factor PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to virus  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in sequestering of triglyceride  
    involved_in skeletal muscle contraction PubMed 
    involved_in toll-like receptor 3 signaling pathway PubMed 
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway PubMed 
    acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway  
    involved_in tumor necrosis factor-mediated signaling pathway  
    involved_in vascular endothelial growth factor production  
    involved_in vascular endothelial growth factor production  
    involved_in vascular endothelial growth factor production  
    involved_in vasodilation PubMed 
    Items 1 - 25 of 245
    Component Evidence Code Pubs
    located_in cell surface  
    located_in external side of plasma membrane PubMed 
    located_in external side of plasma membrane  
    is_active_in extracellular region PubMed 
    located_in extracellular region PubMed 
    is_active_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in membrane raft  
    located_in neuronal cell body PubMed 
    located_in phagocytic cup  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in recycling endosome  

    General protein information

    Preferred Names
    tumor necrosis factor
    Names
    cachectin
    tumor necrosis factor (TNF superfamily, member 2)
    tumor necrosis factor ligand superfamily member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012675.3NP_036807.1  tumor necrosis factor

      See identical proteins and their annotated locations for NP_036807.1

      Status: VALIDATED

      Source sequence(s)
      BX883046
      UniProtKB/Swiss-Prot
      P16599, Q6EE11, Q9JI26, Q9JI27
      UniProtKB/TrEMBL
      A6KTW8, E7DB74
      Related
      ENSRNOP00000107530.1, ENSRNOT00000154879.1
      Conserved Domains (1) summary
      pfam00229
      Location:105235
      TNF; TNF(tumor Necrosis Factor) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3626685..3629303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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