Utrn utrophin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Utrnprovided by RGD
Official Full Name: utrophinprovided by RGD
Primary source: RGD:3947
See related: EnsemblRapid:ENSRNOG00000011058 AllianceGenome:RGD:3947
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DRP-1
Summary: Enables actin filament binding activity. Involved in neuromuscular junction development and response to denervation involved in regulation of muscle adaptation. Located in cortical actin cytoskeleton; growth cone; and neuromuscular junction. Orthologous to human UTRN (utrophin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 386.4), Adrenal (RPKM 269.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p13

Exon count:: 86

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (8541061..9044487, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (6720854..7224313, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (6451809..6970040, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

N-utro may be responsible for the anchoring of the cortical actin cytoskeleton to the membranes in muscle and other tissues.
Title: Tissue expression and actin binding of a novel N-terminal utrophin isoform.
Alterations in the immunoreactivities and expressions of beta-dystroglycan, utrophin, and laminin seem to correlate with angiogenesis rather than BBB disruption during cerebral hypoperfusion.
Title: Dynamics of dystroglycan complex proteins and laminin changes due to angiogenesis in rat cerebral hypoperfusion.
utrophin contributes to the proper functioning of the cerebrospinal fluid and blood-brain barriers
Title: The role of utrophin and Dp71 for assembly of different dystrophin-associated protein complexes (DPCs) in the choroid plexus and microvasculature of the brain.
RhoA activation up-regulates utrophin levels and enhances its localization at the plasma membrane
Title: The GTPase RhoA increases utrophin expression and stability, as well as its localization at the plasma membrane.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143735 (e-PCR)
- UniSTS:232981

D1UIA13 (e-PCR)
- UniSTS:239694

D1Got6 (e-PCR)
- UniSTS:113004

AU049853 (e-PCR)
- UniSTS:146299

RH136661 (e-PCR)
- UniSTS:218752

BE109160 (e-PCR)
- UniSTS:248202

RH94747 (e-PCR)
- UniSTS:119994

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables vinculin binding	IEA Inferred from Electronic Annotation more info
enables vinculin binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in neuromuscular junction development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in response to denervation involved in regulation of muscle adaptation	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in contractile ring	IEA Inferred from Electronic Annotation more info
located_in contractile ring	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of dystrophin-associated glycoprotein complex	IEA Inferred from Electronic Annotation more info
part_of dystrophin-associated glycoprotein complex	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	IEA Inferred from Electronic Annotation more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane bounded cell projection	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: utrophin

Names: dystrophin-related protein 1; utrophin (homologous to dystrophin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013070.2 → NP_037202.2 utrophin

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

G3V7L1

UniProtKB/TrEMBL

O55147

Related

ENSRNOP00000016273.7, ENSRNOT00000016273.7

Conserved Domains (8) summary

cd00176
Location:310 → 528

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2804 → 2832

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3055 → 3103

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:880 → 1827

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16247
Location:2869 → 3030

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:31 → 137

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:152 → 255

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:543 → 646

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

8541061..9044487 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008758594.4 → XP_008756816.1 utrophin isoform X2

See identical proteins and their annotated locations for XP_008756816.1

UniProtKB/Swiss-Prot

G3V7L1

UniProtKB/TrEMBL

O55147

Conserved Domains (8) summary

cd00176
Location:310 → 528

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2804 → 2832

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3055 → 3103

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:880 → 1827

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16247
Location:2869 → 3030

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:31 → 137

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:152 → 255

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:543 → 646

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_008758593.3 → XP_008756815.1 utrophin isoform X2

See identical proteins and their annotated locations for XP_008756815.1

UniProtKB/Swiss-Prot

G3V7L1

UniProtKB/TrEMBL

O55147

Conserved Domains (8) summary

cd00176
Location:310 → 528

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2804 → 2832

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3055 → 3103

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:880 → 1827

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16247
Location:2869 → 3030

EFh_UTRO; EF-hand-like motif found in utrophin

cd21232
Location:31 → 137

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:152 → 255

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:543 → 646

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063281961.1 → XP_063138031.1 utrophin isoform X5

UniProtKB/TrEMBL

O55147
XM_039101949.2 → XP_038957877.1 utrophin isoform X6

UniProtKB/TrEMBL

O55147

Conserved Domains (8) summary

cd00176
Location:255 → 473

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2749 → 2777

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3000 → 3048

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:825 → 1772

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16247
Location:2814 → 2975

EFh_UTRO; EF-hand-like motif found in utrophin

cd21234
Location:97 → 200

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl00030
Location:1 → 82

CH_SF; calponin homology (CH) domain superfamily

cl02488
Location:488 → 591

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101947.2 → XP_038957875.1 utrophin isoform X6

UniProtKB/TrEMBL

O55147

Conserved Domains (8) summary

cd00176
Location:255 → 473

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2749 → 2777

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3000 → 3048

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:825 → 1772

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16247
Location:2814 → 2975

EFh_UTRO; EF-hand-like motif found in utrophin

cd21234
Location:97 → 200

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl00030
Location:1 → 82

CH_SF; calponin homology (CH) domain superfamily

cl02488
Location:488 → 591

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_008758596.4 → XP_008756818.1 utrophin isoform X4

UniProtKB/TrEMBL

A0A8I5ZYU2, O55147

Conserved Domains (7) summary

cd00014
Location:23 → 126

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:301 → 519

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2795 → 2823

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3046 → 3094

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:2824 → 2942

EF-hand_2; EF hand

pfam09069
Location:2946 → 3037

EF-hand_3; EF-hand

cl02488
Location:903 → 1114

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063281964.1 → XP_063138034.1 utrophin isoform X6

UniProtKB/TrEMBL

O55147
XM_008758595.4 → XP_008756817.1 utrophin isoform X3

UniProtKB/TrEMBL

A0A8I6AG96

Conserved Domains (7) summary

cd00014
Location:37 → 140

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:315 → 533

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2809 → 2837

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3060 → 3108

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:2838 → 2956

EF-hand_2; EF hand

pfam09069
Location:2960 → 3051

EF-hand_3; EF-hand

cl02488
Location:917 → 1128

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_006227637.5 → XP_006227699.1 utrophin isoform X1

UniProtKB/TrEMBL

A0A0G2JW60, O55147

Related

ENSRNOP00000069754.1, ENSRNOT00000086574.3

Conserved Domains (7) summary

cd00014
Location:37 → 140

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:315 → 533

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2809 → 2837

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:3060 → 3108

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:2838 → 2956

EF-hand_2; EF hand

pfam09069
Location:2960 → 3051

EF-hand_3; EF-hand

cl02488
Location:917 → 1128

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_039101956.2 → XP_038957884.1 utrophin isoform X8

UniProtKB/TrEMBL

O55147

Conserved Domains (6) summary

cd00176
Location:1 → 173

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:2449 → 2477

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:2700 → 2748

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

TIGR02168
Location:525 → 1472

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd16247
Location:2514 → 2675

EFh_UTRO; EF-hand-like motif found in utrophin

cl02488
Location:188 → 291

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_063281985.1 → XP_063138055.1 utrophin isoform X12
XM_008758598.4 → XP_008756820.1 utrophin isoform X10

UniProtKB/TrEMBL

A0A8I6AE90

Related

ENSRNOP00000092740.1, ENSRNOT00000110616.2

Conserved Domains (6) summary

cd00176
Location:44 → 245

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:372 → 400

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:623 → 671

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:401 → 519

EF-hand_2; EF hand

pfam09069
Location:523 → 614

EF-hand_3; EF-hand

cl02600
Location:873 → 909

HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
XM_063281990.1 → XP_063138060.1 utrophin isoform X13
XM_008758599.4 → XP_008756821.1 utrophin isoform X11

UniProtKB/TrEMBL

A0A8I5ZS09

Related

ENSRNOP00000080968.1, ENSRNOT00000110380.2

Conserved Domains (6) summary

cd00176
Location:7 → 214

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd00201
Location:341 → 369

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd02334
Location:592 → 640

ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...

pfam09068
Location:370 → 488

EF-hand_2; EF hand

pfam09069
Location:492 → 583

EF-hand_3; EF-hand

cl02600
Location:842 → 878

HTH_MerR-SF; Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily
XM_063281969.1 → XP_063138039.1 utrophin isoform X7

UniProtKB/TrEMBL

A0A8I6AG96
XM_039101962.2 → XP_038957890.1 utrophin isoform X9

Conserved Domains (4) summary

cd00176
Location:315 → 533

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cd21232
Location:36 → 142

CH_UTRN_rpt1; first calponin homology (CH) domain found in utrophin and similar proteins

cd21234
Location:157 → 260

CH_UTRN_rpt2; second calponin homology (CH) domain found in utrophin and similar proteins

cl02488
Location:2222 → 2426

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...