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    Fbxl17 F-box and leucine-rich repeat protein 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316663, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxl17provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 17provided by RGD
    Primary source
    RGD:1309773
    See related
    EnsemblRapid:ENSRNOG00000081964 AllianceGenome:RGD:1309773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein polyubiquitination; proteolysis involved in protein catabolic process; and regulation of smoothened signaling pathway. Predicted to be located in nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXL17 (F-box and leucine rich repeat protein 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 210.8), Kidney (RPKM 178.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fbxl17 in Genome Data Viewer
    Location:
    9q37
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (110227609..110666184, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (102780573..103206978, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (110515558..110936631, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480427 Neighboring gene uncharacterized LOC120094760 Neighboring gene tubulin alpha-1B chain-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480616 Neighboring gene uncharacterized LOC134480614 Neighboring gene uncharacterized LOC134480615 Neighboring gene uncharacterized LOC120094810

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    F-box/LRR-repeat protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108235.2NP_001101705.2  F-box/LRR-repeat protein 17

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D3ZVD0
      Related
      ENSRNOP00000100173.1, ENSRNOT00000155382.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      110227609..110666184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083777.2XP_038939705.1  F-box/LRR-repeat protein 17 isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:406568
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:357382
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:316361
      F-box-like
    2. XM_063267332.1XP_063123402.1  F-box/LRR-repeat protein 17 isoform X6

      UniProtKB/TrEMBL
      A6JRA1
    3. XM_039083781.2XP_038939709.1  F-box/LRR-repeat protein 17 isoform X5

      Conserved Domains (3) summary
      cd09293
      Location:406580
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:357382
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:316361
      F-box-like
    4. XM_039083778.2XP_038939706.1  F-box/LRR-repeat protein 17 isoform X2

      Conserved Domains (3) summary
      cd09293
      Location:406568
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:357382
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:316361
      F-box-like
    5. XM_063267329.1XP_063123399.1  F-box/LRR-repeat protein 17 isoform X2

    6. XM_063267330.1XP_063123400.1  F-box/LRR-repeat protein 17 isoform X3

    7. XM_063267331.1XP_063123401.1  F-box/LRR-repeat protein 17 isoform X4

    8. XM_039083780.2XP_038939708.1  F-box/LRR-repeat protein 17 isoform X4

      Conserved Domains (3) summary
      cd09293
      Location:406568
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:357382
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:316361
      F-box-like
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