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    Fbxl17 F-box and leucine-rich repeat protein 17 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316663, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbxl17provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 17provided by RGD
    Primary source
    RGD:1309773
    See related
    EnsemblRapid:ENSRNOG00000081964 AllianceGenome:RGD:1309773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein polyubiquitination; proteolysis involved in protein catabolic process; and regulation of smoothened signaling pathway. Predicted to be located in nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXL17 (F-box and leucine rich repeat protein 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 210.8), Kidney (RPKM 178.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl17 in Genome Data Viewer
    Location:
    9q37
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (110227609..110666184, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (102780573..103206978, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (110515558..110936631, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480427 Neighboring gene uncharacterized LOC120094760 Neighboring gene tubulin alpha-1B chain-like Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480616 Neighboring gene uncharacterized LOC134480614 Neighboring gene uncharacterized LOC134480615 Neighboring gene uncharacterized LOC120094810

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development. Raducu M, et al. EMBO J, 2016 Jul 1. PMID 27234298, Free PMC Article
    2. Dimerization quality control ensures neuronal development and survival. Mena EL, et al. Science, 2018 Oct 12. PMID 30190310
    3. Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover. Tan MK, et al. Mol Cell, 2013 Oct 10. PMID 24035498, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108235.2 → NP_001101705.2  F-box/LRR-repeat protein 17

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      D3ZVD0
      Related
      ENSRNOP00000100173.1, ENSRNOT00000155382.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      110227609..110666184 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083777.2 → XP_038939705.1  F-box/LRR-repeat protein 17 isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:406 → 568
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:357 → 382
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:316 → 361
      F-box-like

    2. XM_063267332.1 → XP_063123402.1  F-box/LRR-repeat protein 17 isoform X6

      UniProtKB/TrEMBL
      A6JRA1

    3. XM_039083781.2 → XP_038939709.1  F-box/LRR-repeat protein 17 isoform X5

      Conserved Domains (3) summary
      cd09293
      Location:406 → 580
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:357 → 382
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:316 → 361
      F-box-like

    4. XM_039083778.2 → XP_038939706.1  F-box/LRR-repeat protein 17 isoform X2

      Conserved Domains (3) summary
      cd09293
      Location:406 → 568
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:357 → 382
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:316 → 361
      F-box-like

    5. XM_063267329.1 → XP_063123399.1  F-box/LRR-repeat protein 17 isoform X2

    6. XM_063267330.1 → XP_063123400.1  F-box/LRR-repeat protein 17 isoform X3

    7. XM_063267331.1 → XP_063123401.1  F-box/LRR-repeat protein 17 isoform X4

    8. XM_039083780.2 → XP_038939708.1  F-box/LRR-repeat protein 17 isoform X4

      Conserved Domains (3) summary
      cd09293
      Location:406 → 568
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:357 → 382
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:316 → 361
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version

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