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    Mapk14 mitogen activated protein kinase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81649, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mapk14provided by RGD
    Official Full Name
    mitogen activated protein kinase 14provided by RGD
    Primary source
    RGD:70496
    See related
    EnsemblRapid:ENSRNOG00000000513 AllianceGenome:RGD:70496
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RK; Hog; p38; CRK1; CSBP; Exip; Mxi2; CSPB1; Csbp1; Csbp2; Prkm14; Prkm15; Sapk2A; p38Hog; p38alpha
    Summary
    Enables ATP binding activity and MAP kinase activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; protein autophosphorylation; and stress-activated MAPK cascade. Predicted to be located in mitochondrion; nuclear speck; and spindle pole. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease; anti-basement membrane glomerulonephritis; and interstitial cystitis. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 267.1), Adrenal (RPKM 258.5) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mapk14 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (6751288..6812294)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (6749646..6810590)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5933290..5995137)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene SRSF protein kinase 1 Neighboring gene uncharacterized LOC120098971 Neighboring gene solute carrier family 26 member 8 Neighboring gene uncharacterized LOC134483779 Neighboring gene mitogen activated protein kinase 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC105413

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding PubMed 
    enables ATP binding  
    enables JUN kinase activity  
    enables MAP kinase activity PubMed 
    enables MAP kinase activity  
    enables MAP kinase activity  
    enables MAP kinase activity PubMed 
    enables MAP kinase activity PubMed 
    enables NFAT protein binding  
    enables NFAT protein binding  
    enables enzyme binding  
    enables kinase activity  
    enables mitogen-activated protein kinase p38 binding  
    enables mitogen-activated protein kinase p38 binding  
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein phosphatase binding  
    enables protein phosphatase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    Items 1 - 25 of 132
    Process Evidence Code Pubs
    involved_in D-glucose import  
    acts_upstream_of D-glucose import  
    involved_in DNA damage checkpoint signaling  
    acts_upstream_of_or_within DNA damage checkpoint signaling  
    acts_upstream_of_or_within DNA damage response  
    involved_in JNK cascade  
    involved_in MAPK cascade  
    involved_in MAPK cascade  
    involved_in angiogenesis  
    acts_upstream_of_or_within angiogenesis  
    involved_in apoptotic process  
    involved_in bone development  
    involved_in bone development  
    involved_in cartilage condensation  
    involved_in cartilage condensation  
    involved_in cell morphogenesis  
    acts_upstream_of_or_within cell morphogenesis  
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway  
    involved_in cellular response to UV-B  
    involved_in cellular response to UV-B  
    involved_in cellular response to ionizing radiation  
    involved_in cellular response to ionizing radiation  
    acts_upstream_of_or_within cellular response to lipopolysaccharide  
    involved_in cellular response to lipoteichoic acid  
    involved_in cellular response to lipoteichoic acid  
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    involved_in cellular response to tumor necrosis factor  
    acts_upstream_of_or_within cellular response to tumor necrosis factor  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in cellular response to vascular endothelial growth factor stimulus  
    involved_in cellular response to virus  
    involved_in chondrocyte differentiation  
    acts_upstream_of_or_within chondrocyte differentiation  
    involved_in chondrocyte differentiation  
    involved_in fatty acid oxidation  
    acts_upstream_of_or_within fatty acid oxidation  
    involved_in glucose metabolic process  
    acts_upstream_of_or_within glucose metabolic process  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction PubMed 
    involved_in intracellular signal transduction PubMed 
    involved_in lipopolysaccharide-mediated signaling pathway  
    acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of canonical Wnt signaling pathway  
    involved_in negative regulation of hippo signaling  
    involved_in negative regulation of hippo signaling  
    involved_in osteoblast differentiation  
    involved_in osteoblast differentiation  
    involved_in osteoclast differentiation  
    involved_in osteoclast differentiation  
    involved_in p38MAPK cascade  
    involved_in p38MAPK cascade  
    involved_in p38MAPK cascade  
    acts_upstream_of_or_within peptidyl-serine phosphorylation  
    involved_in peptidyl-serine phosphorylation  
    involved_in phosphorylation  
    involved_in placenta development  
    acts_upstream_of_or_within placenta development  
    involved_in positive regulation of D-glucose import  
    acts_upstream_of_or_within positive regulation of D-glucose import  
    NOT involved_in positive regulation of blood vessel endothelial cell migration  
    involved_in positive regulation of brown fat cell differentiation  
    acts_upstream_of_or_within positive regulation of brown fat cell differentiation  
    involved_in positive regulation of cardiac muscle cell proliferation  
    acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation  
    involved_in positive regulation of cyclase activity  
    involved_in positive regulation of erythrocyte differentiation  
    acts_upstream_of_or_within positive regulation of erythrocyte differentiation  
    involved_in positive regulation of erythrocyte differentiation  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of myoblast differentiation  
    involved_in positive regulation of myoblast differentiation  
    involved_in positive regulation of myoblast differentiation  
    involved_in positive regulation of myoblast fusion  
    involved_in positive regulation of myoblast fusion  
    involved_in positive regulation of myoblast fusion  
    involved_in positive regulation of myotube differentiation  
    involved_in positive regulation of myotube differentiation  
    involved_in positive regulation of myotube differentiation  
    involved_in positive regulation of protein import into nucleus  
    acts_upstream_of_or_within positive regulation of protein import into nucleus  
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in positive regulation of reactive oxygen species metabolic process  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in protein autophosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within protein phosphorylation  
    involved_in protein phosphorylation PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription  
    involved_in regulation of cytokine production involved in inflammatory response  
    involved_in regulation of cytokine production involved in inflammatory response  
    involved_in regulation of ossification  
    acts_upstream_of_or_within regulation of ossification  
    involved_in regulation of synaptic membrane adhesion  
    involved_in regulation of synaptic membrane adhesion  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to dietary excess  
    involved_in response to dietary excess  
    involved_in response to glucose PubMed 
    involved_in response to insulin  
    involved_in response to insulin  
    acts_upstream_of_or_within response to lipopolysaccharide  
    involved_in response to muramyl dipeptide  
    acts_upstream_of_or_within response to muramyl dipeptide  
    involved_in response to muscle stretch  
    acts_upstream_of_or_within response to muscle stretch  
    involved_in signal transduction in response to DNA damage  
    involved_in skeletal muscle tissue development  
    acts_upstream_of_or_within skeletal muscle tissue development  
    involved_in stem cell differentiation  
    acts_upstream_of_or_within stem cell differentiation  
    involved_in stress-activated MAPK cascade PubMed 
    involved_in stress-activated MAPK cascade  
    involved_in stress-activated MAPK cascade  
    involved_in stress-activated protein kinase signaling cascade  
    involved_in stress-induced premature senescence  
    involved_in stress-induced premature senescence  
    involved_in striated muscle cell differentiation  
    acts_upstream_of_or_within striated muscle cell differentiation  
    involved_in transcription by RNA polymerase II  
    acts_upstream_of transcription by RNA polymerase II  
    involved_in vascular endothelial growth factor receptor signaling pathway  
    involved_in vascular endothelial growth factor receptor signaling pathway  
    Items 1 - 25 of 132
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytosol  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nuclear speck  
    located_in nuclear speck  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus PubMed 
    located_in spindle pole  
    located_in spindle pole  

    General protein information

    Preferred Names
    mitogen-activated protein kinase 14
    Names
    Csaids binding protein
    MAP kinase 14
    MAP kinase 2
    MAP kinase Mxi2
    MAP kinase p38 alpha
    MAPK 14
    MAX-interacting protein 2
    cytokine suppressive anti-inflammatory drug binding protein
    cytokine-supressive anti-inflammatory drug binding protein
    mitogen-activated protein kinase 14A
    mitogen-activated protein kinase p38 alpha
    p38 MAP kinase
    p38 mitogen activated protein kinase
    p38alpha Exip
    reactive kinase
    stress-activated protein kinase 2A
    NP_112282.2
    XP_006256204.1
    XP_063135629.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031020.3NP_112282.2  mitogen-activated protein kinase 14

      See identical proteins and their annotated locations for NP_112282.2

      Status: VALIDATED

      Source sequence(s)
      BC092193, JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I5ZT48, A8C151, Q56A33
      Related
      ENSRNOP00000000617.3, ENSRNOT00000000617.10
      Conserved Domains (1) summary
      cd07877
      Location:6350
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      6751288..6812294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279559.1XP_063135629.1  mitogen-activated protein kinase 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZV37, A0A8I6AEN7
      Related
      ENSRNOP00000090625.1, ENSRNOT00000098053.2
    2. XM_006256142.5XP_006256204.1  mitogen-activated protein kinase 14 isoform X1

      See identical proteins and their annotated locations for XP_006256204.1

      UniProtKB/Swiss-Prot
      O08594, P70618, Q99MG4
      UniProtKB/TrEMBL
      A6JJR8, G3V617
      Related
      ENSRNOP00000000618.2, ENSRNOT00000000618.8
      Conserved Domains (1) summary
      cd07877
      Location:6350
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
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