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    Nono non-POU domain containing, octamer-binding [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317259, updated on 4-Jan-2025

    Summary

    Official Symbol
    Nonoprovided by RGD
    Official Full Name
    non-POU domain containing, octamer-bindingprovided by RGD
    Primary source
    RGD:1549738
    See related
    EnsemblRapid:ENSRNOG00000003689 AllianceGenome:RGD:1549738
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables lncRNA binding activity. Involved in several processes, including cellular response to angiotensin; cellular response to hypoxia; and circadian rhythm. Predicted to be located in fibrillar center; nuclear matrix; and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in paraspeckles. Human ortholog(s) of this gene implicated in cardiomyopathy; intellectual disability; and syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 895.9), Spleen (RPKM 583.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nono in Genome Data Viewer
    Location:
    Xq22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (70594116..70611976)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (66554131..66571992)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (71324365..71342225)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene gap junction protein, beta 1 Neighboring gene zinc finger MYM-type containing 3 Neighboring gene small nucleolar RNA SNORA4 Neighboring gene integrin subunit beta 1 binding protein 2 Neighboring gene TATA-box binding protein associated factor 1 Neighboring gene small nucleolar RNA SNORA26

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC109026

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables RNA binding  
    enables chromatin binding  
    enables identical protein binding  
    enables lncRNA binding PubMed 
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination  
    involved_in DNA repair  
    involved_in RNA splicing  
    involved_in activation of innate immune response  
    involved_in cellular response to angiotensin PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in circadian rhythm PubMed 
    involved_in innate immune response  
    involved_in mRNA processing  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex  
    located_in chromosome  
    located_in fibrillar center  
    located_in nuclear matrix  
    located_in nuclear speck  
    located_in nucleolus  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    is_active_in paraspeckles  
    located_in paraspeckles  

    General protein information

    Preferred Names
    non-POU domain-containing octamer-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012356.1NP_001012356.1  non-POU domain-containing octamer-binding protein

      See identical proteins and their annotated locations for NP_001012356.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089880
      UniProtKB/Swiss-Prot
      Q5FVM4
      UniProtKB/TrEMBL
      A6IQB9, A6IQC0
      Related
      ENSRNOP00000004911.4, ENSRNOT00000004911.7
      Conserved Domains (3) summary
      cd12946
      Location:224316
      NOPS_p54nrb_PSF_PSPC1; NOPS domain, including C-terminal coiled-coil region, in p54nrb/PSF/PSPC1 family proteins
      cd12588
      Location:78148
      RRM1_p54nrb; RNA recognition motif 1 in vertebrate 54 kDa nuclear RNA- and DNA-binding protein (p54nrb)
      cl17169
      Location:154233
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      70594116..70611976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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