Fnta farnesyltransferase, CAAX box, subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fntaprovided by RGD
Official Full Name: farnesyltransferase, CAAX box, subunit alphaprovided by RGD
Primary source: RGD:2625
See related: EnsemblRapid:ENSRNOG00000014462 AllianceGenome:RGD:2625
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PFAS
Summary: Contributes to several functions, including peptide binding activity; protein prenyltransferase activity; and zinc ion binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell population proliferation; and regulation of nitric-oxide synthase biosynthetic process. Part of CAAX-protein geranylgeranyltransferase complex. Orthologous to human FNTA (farnesyltransferase, CAAX box, subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 251.5), Kidney (RPKM 234.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.4

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (72767864..72786193)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (66065131..66083460)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (70834957..70854724)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that substrate specificity of protein farnesyltransferase (subunits Fnta plus Fntb) is extensive; these results expand the scope of the potential prenylated proteome in this species. (Fnta = farnesyltransferase CAAX box alpha protein; Fntb = farnesyltransferase CAAX box beta protein)
Title: Efficient farnesylation of an extended C-terminal C(x)(3)X sequence motif expands the scope of the prenylated proteome.
GGTase-1 mediates brain derived neurotrophic factor (BDNF)-induced neuronal synaptogenesis in the hippocampus.
Title: Geranylgeranyltransferase I mediates BDNF-induced synaptogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8Rck2 (e-PCR), detects polymorphism
- UniSTS:142728

RH94481 (e-PCR)
- UniSTS:119729

BI282482 (e-PCR)
- UniSTS:249800

BI274352 (e-PCR)
- UniSTS:249063

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to CAAX-protein geranylgeranyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to CAAX-protein geranylgeranyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables Rab geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables Rab geranylgeranyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
contributes_to heterocyclic compound binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
contributes_to peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to protein farnesyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to protein farnesyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein farnesyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein farnesyltransferase activity	IEA Inferred from Electronic Annotation more info
contributes_to protein farnesyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein farnesyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein geranylgeranyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein geranylgeranyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables receptor tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
contributes_to small molecule binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in enzyme-linked receptor protein signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in enzyme-linked receptor protein signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide pheromone maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rac protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of deacetylase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tubulin deacetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in protein farnesylation	ISO Inferred from Sequence Orthology more info
involved_in protein farnesylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein geranylgeranylation	ISO Inferred from Sequence Orthology more info
involved_in protein geranylgeranylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle acetylcholine-gated channel clustering	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CAAX-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CAAX-protein geranylgeranyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of CAAX-protein geranylgeranyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of CAAX-protein geranylgeranyltransferase complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of microtubule associated complex	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein farnesyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein farnesyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of protein farnesyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of protein farnesyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Names: CAAX farnesyltransferase subunit alpha; FTase-alpha; Farnesyltransferase, subunit alpha; GGTase-I-alpha; farnesyltransferase, CAAX box, alpha; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase subunit alpha

NP_036979.2

EC 2.5.1.58

EC 2.5.1.59

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012847.2 → NP_036979.2 protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000016

UniProtKB/Swiss-Prot

Q04631

UniProtKB/TrEMBL

F7FMZ5, Q5RKJ4

Related

ENSRNOP00000019594.3, ENSRNOT00000019594.6

Conserved Domains (1) summary

PLN02789
Location:64 → 365

PLN02789; farnesyltranstransferase