U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Lamc1 laminin subunit gamma 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117036, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lamc1provided by RGD
    Official Full Name
    laminin subunit gamma 1provided by RGD
    Primary source
    RGD:621052
    See related
    EnsemblRapid:ENSRNOG00000002680 AllianceGenome:RGD:621052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    B2e
    Summary
    Predicted to enable glycosphingolipid binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including hair follicle cell proliferation; hair follicle morphogenesis; and neuron differentiation. Predicted to act upstream of or within neuron projection development. Located in collagen-containing extracellular matrix. Part of laminin-1 complex. Orthologous to human LAMC1 (laminin subunit gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 919.8), Muscle (RPKM 535.9) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lamc1 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (67924872..68051986, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65374372..65501492, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (70656727..70783515, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096279 Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene laminin subunit gamma 2 Neighboring gene ornithine decarboxylase-like Neighboring gene SHC binding and spindle associated 1 like Neighboring gene DExH-box helicase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in animal organ morphogenesis  
    involved_in axon guidance  
    involved_in cell adhesion  
    involved_in cell migration  
    involved_in chromatin organization  
    involved_in extracellular matrix disassembly  
    involved_in gene expression  
    involved_in hair cell differentiation  
    involved_in hair follicle cell proliferation  
    involved_in hair follicle morphogenesis  
    involved_in hemidesmosome assembly  
    acts_upstream_of_or_within neuron projection development  
    involved_in protein-containing complex assembly  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in tissue development  
    involved_in tissue morphogenesis  
    Component Evidence Code Pubs
    is_active_in basement membrane  
    located_in basement membrane  
    located_in collagen-containing extracellular matrix PubMed 
    part_of laminin-1 complex PubMed 
    part_of laminin-10 complex  
    is_active_in neuromuscular junction  
    is_active_in synaptic cleft  

    General protein information

    Preferred Names
    laminin subunit gamma-1
    Names
    laminin, gamma 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053966.3NP_446418.1  laminin subunit gamma-1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICU8, F1MAA7
      Related
      ENSRNOP00000003605.5, ENSRNOT00000003605.9
      Conserved Domains (10) summary
      smart00136
      Location:42282
      LamNT; Laminin N-terminal domain (domain VI)
      smart00180
      Location:933978
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      smart00281
      Location:552676
      LamB; Laminin B domain
      smart00283
      Location:10891300
      MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)
      cd00055
      Location:9801027
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cl21499
      Location:15181588
      SPX; Domain found in Syg1, Pho81, XPR1, and related proteins
      pfam00053
      Location:443490
      Laminin_EGF; Laminin EGF domain
      pfam00261
      Location:13551586
      Tropomyosin; Tropomyosin
      cl09111
      Location:14161551
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl09176
      Location:10481121
      FlgN; FlgN protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      67924872..68051986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.