Tas1r1 taste 1 receptor member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tas1r1provided by RGD
Official Full Name: taste 1 receptor member 1provided by RGD
Primary source: RGD:61891
See related: EnsemblRapid:ENSRNOG00000009708 AllianceGenome:RGD:61891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr70
Summary: Enables taste receptor activity. Involved in sensory perception of umami taste. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human TAS1R1 (taste 1 receptor member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 68.4), Adrenal (RPKM 39.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (167816566..167829136, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (162533838..162546408, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (169200389..169212113, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables taste receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables taste receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of umami taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of umami taste	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of umami taste	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: taste receptor type 1 member 1

Names: G-protein coupled receptor 70; taste receptor, type 1, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053305.1 → NP_445757.1 taste receptor type 1 member 1 precursor

See identical proteins and their annotated locations for NP_445757.1

Status: VALIDATED

Source sequence(s)

AF127389, CR460546

UniProtKB/Swiss-Prot

Q9Z0R8

UniProtKB/TrEMBL

A6IUG3

Related

ENSRNOP00000013385.3, ENSRNOT00000013385.7

Conserved Domains (3) summary

cd15289
Location:564 → 816

7tmC_TAS1R1; type 1 taste receptor subtype 1, member of the class C of seven-transmembrane G protein-coupled receptors

cd06363
Location:31 → 492

PBP1_taste_receptor; ligand-binding domain of the T1R taste receptor

pfam07562
Location:492 → 544

NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

167816566..167829136 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008764341.2 → XP_008762563.1 taste receptor type 1 member 1 isoform X1

UniProtKB/TrEMBL

A6IUG3

Conserved Domains (4) summary

pfam00003
Location:504 → 736

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:1 → 379

ANF_receptor; Receptor family ligand binding region

pfam07562
Location:416 → 466

NCD3G; Nine Cysteines Domain of family 3 GPCR

cl10011
Location:1 → 408

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
XM_039109370.2 → XP_038965298.1 taste receptor type 1 member 1 isoform X2

UniProtKB/TrEMBL

A6IUG4

Conserved Domains (2) summary

cd06363
Location:31 → 492

PBP1_taste_receptor; ligand-binding domain of the T1R taste receptor

pfam07562
Location:492 → 528

NCD3G; Nine Cysteines Domain of family 3 GPCR