U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Osbpl6 oxysterol binding protein-like 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311129, updated on 9-Dec-2024

    Summary

    Official Symbol
    Osbpl6provided by RGD
    Official Full Name
    oxysterol binding protein-like 6provided by RGD
    Primary source
    RGD:1308887
    See related
    EnsemblRapid:ENSRNOG00000010812 AllianceGenome:RGD:1308887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be involved in regulation of cholesterol transport. Predicted to be located in early endosome membrane and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including cytosol; nuclear membrane; and perinuclear endoplasmic reticulum. Orthologous to human OSBPL6 (oxysterol binding protein like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 105.8), Heart (RPKM 101.6) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Osbpl6 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (81751020..81948186)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (61343776..61541170)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (63257646..63455105)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 11A Neighboring gene acidic nuclear phosphoprotein 32 family member A, pseudogene 1 Neighboring gene cytochrome c, testis Neighboring gene RNA binding motif protein 45 Neighboring gene uncharacterized LOC134486118 Neighboring gene protein activator of interferon induced protein kinase EIF2AK2 Neighboring gene pejvakin

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding  
    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in cytosol  
    located_in early endosome membrane  
    located_in endoplasmic reticulum membrane  
    is_active_in nuclear membrane  
    located_in nuclear membrane  
    is_active_in perinuclear endoplasmic reticulum  
    located_in perinuclear endoplasmic reticulum  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    oxysterol-binding protein-related protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107735.2NP_001101205.1  oxysterol-binding protein-related protein 6 isoform d

      See identical proteins and their annotated locations for NP_001101205.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4, A6HMH5
      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:570911
      Oxysterol_BP; Oxysterol-binding protein
    2. NM_001431697.1NP_001418626.1  oxysterol-binding protein-related protein 6 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4
    3. NM_001431698.1NP_001418627.1  oxysterol-binding protein-related protein 6 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4, D4A0F3
    4. NM_001431699.1NP_001418628.1  oxysterol-binding protein-related protein 6 isoform c precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZY24, A6HMH4
    5. NM_001431700.1NP_001418629.1  oxysterol-binding protein-related protein 6 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4, A6HMH5
    6. NM_001431701.1NP_001418630.1  oxysterol-binding protein-related protein 6 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JZR1, A6HMH4
    7. NM_001431702.1NP_001418631.1  oxysterol-binding protein-related protein 6 isoform f precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMH4
    8. NM_001431703.1NP_001418632.1  oxysterol-binding protein-related protein 6 isoform g

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AMZ3, A6HMH4
    9. NM_001431704.1NP_001418633.1  oxysterol-binding protein-related protein 6 isoform h

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    10. NM_001431705.1NP_001418634.1  oxysterol-binding protein-related protein 6 isoform i precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    11. NM_001431706.1NP_001418635.1  oxysterol-binding protein-related protein 6 isoform j

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    12. NM_001431707.1NP_001418636.1  oxysterol-binding protein-related protein 6 isoform k precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    13. NM_001431708.1NP_001418637.1  oxysterol-binding protein-related protein 6 isoform l

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      81751020..81948186
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591693.3XP_017447182.1  oxysterol-binding protein-related protein 6 isoform X1

      Related
      ENSRNOP00000059467.2, ENSRNOT00000068199.4
      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:603944
      Oxysterol_BP; Oxysterol-binding protein
    2. XM_017591695.3XP_017447184.1  oxysterol-binding protein-related protein 6 isoform X2

      Related
      ENSRNOP00000112175.1, ENSRNOT00000151334.1
      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:595936
      Oxysterol_BP; Oxysterol-binding protein
    3. XM_039104857.2XP_038960785.1  oxysterol-binding protein-related protein 6 isoform X8

      UniProtKB/TrEMBL
      A6HMH4
      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:559907
      Oxysterol_BP; Oxysterol-binding protein
    4. XM_017591696.3XP_017447185.1  oxysterol-binding protein-related protein 6 isoform X3

      UniProtKB/TrEMBL
      A6HMH4
      Related
      ENSRNOP00000110453.1, ENSRNOT00000125272.1
      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:578919
      Oxysterol_BP; Oxysterol-binding protein
    5. XM_017591698.3XP_017447187.1  oxysterol-binding protein-related protein 6 isoform X6

      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:570911
      Oxysterol_BP; Oxysterol-binding protein
    6. XM_039104858.2XP_038960786.1  oxysterol-binding protein-related protein 6 isoform X12

      UniProtKB/TrEMBL
      A6HMH4
      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam01237
      Location:534882
      Oxysterol_BP; Oxysterol-binding protein
    7. XM_017591697.3XP_017447186.1  oxysterol-binding protein-related protein 6 isoform X5

      UniProtKB/TrEMBL
      A6HMH4
      Related
      ENSRNOP00000071146.3, ENSRNOT00000091211.3
      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:572913
      Oxysterol_BP; Oxysterol-binding protein
    8. XM_008761904.4XP_008760126.1  oxysterol-binding protein-related protein 6 isoform X7

      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:564905
      Oxysterol_BP; Oxysterol-binding protein
    9. XM_008761905.4XP_008760127.1  oxysterol-binding protein-related protein 6 isoform X10

      UniProtKB/TrEMBL
      A6HMH4
      Related
      ENSRNOP00000095383.2, ENSRNOT00000111872.2
      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:547888
      Oxysterol_BP; Oxysterol-binding protein
    10. XM_008761906.4XP_008760128.1  oxysterol-binding protein-related protein 6 isoform X11

      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:539880
      Oxysterol_BP; Oxysterol-binding protein
    11. XM_063283627.1XP_063139697.1  oxysterol-binding protein-related protein 6 isoform X13

      UniProtKB/TrEMBL
      A0A8I6A0D2, A6HMH4
      Related
      ENSRNOP00000085530.1, ENSRNOT00000109671.2
    12. XM_008761907.3XP_008760129.1  oxysterol-binding protein-related protein 6 isoform X14

      Conserved Domains (2) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
    13. XM_063283628.1XP_063139698.1  oxysterol-binding protein-related protein 6 isoform X15

    14. XM_063283630.1XP_063139700.1  oxysterol-binding protein-related protein 6 isoform X17

    15. XM_063283631.1XP_063139701.1  oxysterol-binding protein-related protein 6 isoform X18

    16. XM_063283633.1XP_063139703.1  oxysterol-binding protein-related protein 6 isoform X20

    17. XM_063283634.1XP_063139704.1  oxysterol-binding protein-related protein 6 isoform X21

    18. XM_017591694.3XP_017447183.1  oxysterol-binding protein-related protein 6 isoform X1

      UniProtKB/TrEMBL
      A6HMH4, D4A0F3
      Conserved Domains (3) summary
      cd13287
      Location:66188
      PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
      pfam00169
      Location:89177
      PH; PH domain
      pfam01237
      Location:603944
      Oxysterol_BP; Oxysterol-binding protein
    19. XM_063283629.1XP_063139699.1  oxysterol-binding protein-related protein 6 isoform X16

    20. XM_063283632.1XP_063139702.1  oxysterol-binding protein-related protein 6 isoform X19

    21. XM_063283625.1XP_063139695.1  oxysterol-binding protein-related protein 6 isoform X4

      Related
      ENSRNOP00000083910.1, ENSRNOT00000112703.2
    22. XM_063283626.1XP_063139696.1  oxysterol-binding protein-related protein 6 isoform X9

    External link. Please review our privacy policy.