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    Phactr2 phosphatase and actin regulator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phactr2provided by RGD
    Official Full Name
    phosphatase and actin regulator 2provided by RGD
    Primary source
    RGD:1303141
    See related
    EnsemblRapid:ENSRNOG00000015473 AllianceGenome:RGD:1303141
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in actin cytoskeleton organization. Human ortholog(s) of this gene implicated in Parkinson's disease and multiple sclerosis. Orthologous to human PHACTR2 (phosphatase and actin regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 232.0), Heart (RPKM 96.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phactr2 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (9411412..9680648, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (7591254..7860431, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (7352050..7633991, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger, C2HC-type containing 1B Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene alpha-L-fucosidase 2 Neighboring gene peroxisomal biogenesis factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase and actin regulator 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214458.2 → NP_999623.2  phosphatase and actin regulator 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P62025
      UniProtKB/TrEMBL
      A6JP58, G3V9F4
      Related
      ENSRNOP00000045608.6, ENSRNOT00000048754.7
      Conserved Domains (2) summary
      smart00707
      Location:451 → 475
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02755
      Location:73 → 94
      RPEL; RPEL repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      9411412..9680648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589103.3 → XP_017444592.1  phosphatase and actin regulator 2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AEE3

    2. XM_017589101.3 → XP_017444590.1  phosphatase and actin regulator 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AEE3
      Related
      ENSRNOP00000090478.2, ENSRNOT00000117080.2

    3. XM_017589098.3 → XP_017444587.1  phosphatase and actin regulator 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AEE3
      Related
      ENSRNOP00000081639.2, ENSRNOT00000103115.2

    4. XM_017589102.3 → XP_017444591.1  phosphatase and actin regulator 2 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AEE3
      Related
      ENSRNOP00000079024.2, ENSRNOT00000095947.2

    5. XM_063288643.1 → XP_063144713.1  phosphatase and actin regulator 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZSY0, A0A8I6G7F9
      Related
      ENSRNOP00000091111.2, ENSRNOT00000098982.2

    6. XM_063288664.1 → XP_063144734.1  phosphatase and actin regulator 2 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZSY0

    7. XM_063288661.1 → XP_063144731.1  phosphatase and actin regulator 2 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZSY0

    8. XM_063288655.1 → XP_063144725.1  phosphatase and actin regulator 2 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZSY0

    9. XM_063288648.1 → XP_063144718.1  phosphatase and actin regulator 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A650

    10. XM_063288641.1 → XP_063144711.1  phosphatase and actin regulator 2 isoform X2

      UniProtKB/Swiss-Prot
      P62025
      Related
      ENSRNOP00000081040.2, ENSRNOT00000118029.2

    11. XM_063288665.1 → XP_063144735.1  phosphatase and actin regulator 2 isoform X14

      UniProtKB/TrEMBL
      A0A8I6A650

    12. XM_063288662.1 → XP_063144732.1  phosphatase and actin regulator 2 isoform X12

      UniProtKB/Swiss-Prot
      P62025

    13. XM_063288660.1 → XP_063144730.1  phosphatase and actin regulator 2 isoform X10

      UniProtKB/Swiss-Prot
      P62025
      UniProtKB/TrEMBL
      A0A8I5ZMK8

    14. XM_063288658.1 → XP_063144728.1  phosphatase and actin regulator 2 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A650, A0A8I6AF00

    15. XM_063288666.1 → XP_063144736.1  phosphatase and actin regulator 2 isoform X15

      UniProtKB/TrEMBL
      A0A8I6A650
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62025.1 GenPept UniProtKB/Swiss-Prot:P62025

    Gene LinkOut

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