Cbx7 chromobox 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cbx7provided by RGD
Official Full Name: chromobox 7provided by RGD
Primary source: RGD:735027
See related: EnsemblRapid:ENSRNOG00000016875 AllianceGenome:RGD:735027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Involved in developmental process involved in reproduction; positive regulation of transcription elongation by RNA polymerase II; and response to xenobiotic stimulus. Predicted to be located in cytosol; heterochromatin; and nucleoplasm. Predicted to be part of PRC1 complex. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 91.5), Lung (RPKM 84.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (113341030..113358716, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (111460656..111479231, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (121136067..121153503, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury.
Title: Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury.
Knockdown of CBX7 inhibits ferroptosis in rats with cerebral ischemia and improves cognitive dysfunction by activating the Nrf2/HO-1 pathway.
Title: Knockdown of CBX7 inhibits ferroptosis in rats with cerebral ischemia and improves cognitive dysfunction by activating the Nrf2/HO-1 pathway.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in developmental process involved in reproduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sebaceous gland development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PRC1 complex	IEA Inferred from Electronic Annotation more info
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PRC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromobox protein homolog 7

Names: chromobox homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199117.2 → NP_954548.1 chromobox protein homolog 7

See identical proteins and their annotated locations for NP_954548.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P60889

UniProtKB/TrEMBL

A6HSV0

Conserved Domains (1) summary

pfam00385
Location:13 → 60

Chromo; Chromo (CHRromatin Organization MOdifier) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

113341030..113358716 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079593.2 → XP_038935521.1 chromobox protein homolog 7 isoform X7

UniProtKB/TrEMBL

A0A8L2UR72

Related

ENSRNOP00000074584.2, ENSRNOT00000077731.3
XM_039079592.2 → XP_038935520.1 chromobox protein homolog 7 isoform X6

Conserved Domains (2) summary

cd18646
Location:7 → 62

CD_Cbx7; chromodomain of chromobox homolog 7

pfam17218
Location:115 → 146

CBX7_C; CBX family C-terminal motif
XM_039079591.2 → XP_038935519.1 chromobox protein homolog 7 isoform X4

Conserved Domains (2) summary

cd18646
Location:7 → 62

CD_Cbx7; chromodomain of chromobox homolog 7

pfam17218
Location:150 → 181

CBX7_C; CBX family C-terminal motif
XM_006242022.5 → XP_006242084.1 chromobox protein homolog 7 isoform X2

Conserved Domains (1) summary

smart00298
Location:10 → 62

CHROMO; Chromatin organization modifier domain
XM_006242020.5 → XP_006242082.1 chromobox protein homolog 7 isoform X1

See identical proteins and their annotated locations for XP_006242082.1

UniProtKB/TrEMBL

A0A8L2QCQ7, A6HSV1

Related

ENSRNOP00000022631.6, ENSRNOT00000022631.8

Conserved Domains (1) summary

smart00298
Location:10 → 62

CHROMO; Chromatin organization modifier domain
XM_039079590.2 → XP_038935518.1 chromobox protein homolog 7 isoform X3

Conserved Domains (1) summary

pfam17218
Location:155 → 186

CBX7_C; CBX family C-terminal motif
XM_063263925.1 → XP_063119995.1 chromobox protein homolog 7 isoform X5
XM_006242021.5 → XP_006242083.1 chromobox protein homolog 7 isoform X1

See identical proteins and their annotated locations for XP_006242083.1

UniProtKB/TrEMBL

A0A8L2QCQ7, A6HSV1

Conserved Domains (1) summary

smart00298
Location:10 → 62

CHROMO; Chromatin organization modifier domain