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    Tapbpl TAP binding protein-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297602, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tapbplprovided by RGD
    Official Full Name
    TAP binding protein-likeprovided by RGD
    Primary source
    RGD:1307893
    See related
    EnsemblRapid:ENSRNOG00000077779 AllianceGenome:RGD:1307893
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable MHC class I protein complex binding activity. Predicted to be involved in negative regulation of antigen processing and presentation of peptide antigen via MHC class I and peptide antigen assembly with MHC class I protein complex. Predicted to be located in endoplasmic reticulum. Orthologous to human TAPBPL (TAP binding protein like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 182.5), Adrenal (RPKM 148.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tapbpl in Genome Data Viewer
    Location:
    4q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159707686..159715137, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (158021454..158028905, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157735748..157743199, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L51 Neighboring gene vesicle-associated membrane protein 1 Neighboring gene uncharacterized LOC120102390 Neighboring gene CD27 molecule Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing. Morozov GI, et al. Proc Natl Acad Sci U S A, 2016 Feb 23. PMID 26869717, Free PMC Article
    2. Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway. Boyle LH, et al. Proc Natl Acad Sci U S A, 2013 Feb 26. PMID 23401559, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC class I protein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of antigen processing and presentation of peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide antigen assembly with MHC class I protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tapasin-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106622.1 → NP_001100092.1  tapasin-related protein precursor

      See identical proteins and their annotated locations for NP_001100092.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473964
      UniProtKB/TrEMBL
      A6ILT2
      Related
      ENSRNOP00000100879.1, ENSRNOT00000166679.1
      Conserved Domains (3) summary
      smart00410
      Location:205 → 301
      IG_like; Immunoglobulin like
      pfam07686
      Location:205 → 302
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:267 → 397
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159707686..159715137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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