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    Serpinb6a serpin family B member 6A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291085, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serpinb6aprovided by RGD
    Official Full Name
    serpin family B member 6Aprovided by RGD
    Primary source
    RGD:735108
    See related
    EnsemblRapid:ENSRNOG00000017962 AllianceGenome:RGD:735108
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Serpinb6
    Summary
    Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in cellular response to osmotic stress; negative regulation of endopeptidase activity; and sensory perception of sound. Predicted to be part of serine protease inhibitor complex. Predicted to be active in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 91. Orthologous to human SERPINB6 (serpin family B member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 398.9), Heart (RPKM 281.4) and 9 other tissues See more
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    Genomic context

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    See Serpinb6a in Genome Data Viewer
    Location:
    17p12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (31076811..31195035)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (30871468..30989703)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (32154747..32209598)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene tubulin, beta 2A class IIa Neighboring gene biphenyl hydrolase like Neighboring gene receptor interacting serine/threonine kinase 1 Neighboring gene N-ribosyldihydronicotinamide:quinone dehydrogenase 2 Neighboring gene uncharacterized LOC102554685 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6e like 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 6e

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. Strik MC, et al. Blood, 2004 Apr 1. PMID 14670919
    2. Cloning and molecular characterization of a human intracellular serine proteinase inhibitor. Coughlin P, et al. Proc Natl Acad Sci U S A, 1993 Oct 15. PMID 8415716, Free PMC Article
    3. A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss. Sirmaci A, et al. Am J Hum Genet, 2010 May 14. PMID 20451170, Free PMC Article
    4. SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes. Scott FL, et al. J Biochem, 2007 Oct. PMID 17761692
    5. Expression of serpinb6 serpins in germ and somatic cells of mouse gonads. Charron Y, et al. Mol Reprod Dev, 2006 Jan. PMID 16175637

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72983

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of serine protease inhibitor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serpin B6
    Names
    serine (or cysteine) peptidase inhibitor, clade B, member 6a
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6
    serpin family B member 6
    serpin peptidase inhibitor, clade B (ovalbumin), member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395026.1 → NP_001381955.1  serpin B6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6ABJ3, A6J7I2, F7EUC3, Q6P9U0
      Conserved Domains (1) summary
      cd19565
      Location:1 → 379
      serpinB6_CAP; serpin family B member 6, cytoplasmic antiproteinase

    2. NM_001395027.1 → NP_001381956.1  serpin B6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6ABJ3, A6J7I2, F7EUC3, Q6P9U0
      Related
      ENSRNOP00000090303.1, ENSRNOT00000118879.2
      Conserved Domains (1) summary
      cd19565
      Location:1 → 379
      serpinB6_CAP; serpin family B member 6, cytoplasmic antiproteinase

    3. NM_199085.3 → NP_954516.1  serpin B6

      See identical proteins and their annotated locations for NP_954516.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6ABJ3, A6J7I2, F7EUC3, Q6P9U0
      Conserved Domains (1) summary
      cd19565
      Location:1 → 379
      serpinB6_CAP; serpin family B member 6, cytoplasmic antiproteinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      31076811..31195035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095492.2 → XP_038951420.1  serpin B6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABJ3, A6J7I2, F7EUC3, Q6P9U0
      Conserved Domains (1) summary
      cd19565
      Location:1 → 379
      serpinB6_CAP; serpin family B member 6, cytoplasmic antiproteinase

    2. XM_006253871.4 → XP_006253933.1  serpin B6 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6H8, F7EUC3
      Related
      ENSRNOP00000089104.1, ENSRNOT00000102782.2
      Conserved Domains (1) summary
      cl00137
      Location:25 → 400
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    Nucleotide Protein Strain
    Heading Accession and Version

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