Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Appl2provided by RGD
Official Full Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2provided by RGD
Primary source: RGD:1563028
See related: EnsemblRapid:ENSRNOG00000008174 AllianceGenome:RGD:1563028
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563028
Summary: Predicted to enable phosphatidylinositol binding activity; phosphatidylserine binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of metabolic process; and positive regulation of endocytosis. Predicted to be located in cytoplasmic vesicle; nucleus; and ruffle membrane. Predicted to be active in endosome membrane. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 69.7), Testes (RPKM 65.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q13

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (22019480..22072386)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (20135248..20184757)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (26256179..26306128)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129999 (e-PCR)
- UniSTS:213287

D19286 (e-PCR)
- UniSTS:124801

AA850515 (e-PCR)
- UniSTS:261547

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adiponectin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hepatocyte growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cold acclimation	ISO Inferred from Sequence Orthology more info
involved_in diet induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neural precursor cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macropinocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early phagosome	ISO Inferred from Sequence Orthology more info
located_in early phagosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in macropinosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DCC-interacting protein 13-beta

Names: adapter protein containing PH domain, PTB domain and leucine zipper motif 2; adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108741.1 → NP_001102211.1 DCC-interacting protein 13-beta

See identical proteins and their annotated locations for NP_001102211.1

Status: PROVISIONAL

Source sequence(s)

CH473960

UniProtKB/Swiss-Prot

B4F779

UniProtKB/TrEMBL

A0A8I6A8C2

Related

ENSRNOP00000010986.4, ENSRNOT00000010986.7

Conserved Domains (3) summary

cd07632
Location:20 → 234

BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2

cd13158
Location:480 → 613

PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain

cd13247
Location:252 → 376

BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

22019480..22072386

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006241201.5 → XP_006241263.1 DCC-interacting protein 13-beta isoform X1

UniProtKB/TrEMBL

A0A8I6A8C2

Conserved Domains (4) summary

cd07632
Location:20 → 234

BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2

cd13158
Location:480 → 613

PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain

cd13247
Location:252 → 376

BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

pfam00169
Location:278 → 375

PH; PH domain
XM_039079421.2 → XP_038935349.1 DCC-interacting protein 13-beta isoform X2

Conserved Domains (3) summary

cd13158
Location:337 → 470

PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain

cd13247
Location:109 → 233

BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

cl12013
Location:1 → 91

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature