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    Asb6 ankyrin repeat and SOCS box-containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296627, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asb6provided by RGD
    Official Full Name
    ankyrin repeat and SOCS box-containing 6provided by RGD
    Primary source
    RGD:1308445
    See related
    EnsemblRapid:ENSRNOG00000024786 AllianceGenome:RGD:1308445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB6 (ankyrin repeat and SOCS box containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 52.1), Thymus (RPKM 51.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asb6 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34508390..34513033, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14110628..14115274, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9659707..9664445, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 9 open reading frame 50 Neighboring gene N-terminal Xaa-Pro-Lys N-methyltransferase 1 Neighboring gene paired related homeobox 2 Neighboring gene prostaglandin E synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 6
    Names
    ankyrin repeat and SOCS box-containing protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011963.3 → NP_001011963.1  ankyrin repeat and SOCS box protein 6 isoform 2

      See identical proteins and their annotated locations for NP_001011963.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ANG1, Q6AYC9
      Related
      ENSRNOP00000031019.3, ENSRNOT00000034927.5
      Conserved Domains (4) summary
      cd00204
      Location:29 → 139
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03725
      Location:295 → 338
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      pfam12796
      Location:32 → 131
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:30 → 58
      ANK; ANK repeat [structural motif]

    2. NM_001399347.1 → NP_001386276.1  ankyrin repeat and SOCS box protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JU05, A6JU06
      Related
      ENSRNOP00000097464.2, ENSRNOT00000105180.2
      Conserved Domains (3) summary
      PHA03095
      Location:86 → 282
      PHA03095; ankyrin-like protein; Provisional
      cd03725
      Location:368 → 411
      SOCS_ASB6; SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor ...
      sd00045
      Location:103 → 131
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      34508390..34513033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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