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    Abat 4-aminobutyrate aminotransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81632, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abatprovided by RGD
    Official Full Name
    4-aminobutyrate aminotransferaseprovided by RGD
    Primary source
    RGD:620948
    See related
    EnsemblRapid:ENSRNOG00000002636 AllianceGenome:RGD:620948
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gabat; beta-AlaAT
    Summary
    Enables 4-aminobutyrate:2-oxoglutarate transaminase activity. Involved in several processes, including gamma-aminobutyric acid biosynthetic process; positive regulation of inhibitory postsynaptic potential; and regulation of secretion. Located in mitochondrial matrix. Used to study several diseases, including Huntington's disease; depressive disorder; epilepsy (multiple); heroin dependence; and ischemia. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 378.6), Kidney (RPKM 369.5) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Abat in Genome Data Viewer
    Location:
    10q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (7503351..7599474, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (6996688..7092835, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (7093406..7200439, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene phosphomannomutase 2 Neighboring gene transmembrane protein 186 Neighboring gene uncharacterized LOC120095023 Neighboring gene uncharacterized LOC134480750 Neighboring gene methyltransferase 22, Kin17 lysine

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93392

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables (S)-3-amino-2-methylpropionate transaminase activity  
    enables 4-aminobutyrate:2-oxoglutarate transaminase activity PubMed 
    contributes_to 4-aminobutyrate:2-oxoglutarate transaminase activity  
    enables 4-aminobutyrate:2-oxoglutarate transaminase activity  
    contributes_to 4-aminobutyrate:2-oxoglutarate transaminase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables iron-sulfur cluster binding  
    enables metal ion binding  
    enables protein homodimerization activity  
    enables pyridoxal phosphate binding  
    enables pyridoxal phosphate binding  
    enables pyridoxal phosphate binding  
    enables pyridoxal phosphate binding  
    enables succinate-semialdehyde dehydrogenase binding  
    enables succinate-semialdehyde dehydrogenase binding  
    enables transaminase activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in behavioral response to cocaine  
    involved_in cerebellum development PubMed 
    involved_in copulation PubMed 
    involved_in exploration behavior PubMed 
    involved_in gamma-aminobutyric acid biosynthetic process PubMed 
    involved_in gamma-aminobutyric acid catabolic process  
    involved_in gamma-aminobutyric acid catabolic process  
    involved_in gamma-aminobutyric acid metabolic process  
    involved_in locomotory behavior PubMed 
    involved_in negative regulation of blood pressure PubMed 
    involved_in negative regulation of dopamine secretion PubMed 
    involved_in negative regulation of gamma-aminobutyric acid secretion PubMed 
    involved_in nervous system process  
    involved_in positive regulation of aspartate secretion PubMed 
    involved_in positive regulation of dopamine metabolic process PubMed 
    involved_in positive regulation of heat generation PubMed 
    involved_in positive regulation of inhibitory postsynaptic potential PubMed 
    involved_in positive regulation of insulin secretion PubMed 
    involved_in positive regulation of prolactin secretion PubMed 
    involved_in positive regulation of uterine smooth muscle contraction PubMed 
    involved_in response to cocaine PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to iron ion PubMed 
    involved_in response to nicotine PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    part_of 4-aminobutyrate transaminase complex  
    part_of 4-aminobutyrate transaminase complex  
    located_in mitochondrial matrix PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion  

    General protein information

    Preferred Names
    4-aminobutyrate aminotransferase, mitochondrial
    Names
    (S)-3-amino-2-methylpropionate transaminase
    GABA aminotransferase
    GABA transaminase
    GABA-AT
    GABA-T
    L-AIBAT
    beta-AlaAT I
    gamma-amino-N-butyrate transaminase
    NP_112265.1
    XP_006245822.1
    XP_063126013.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031003.2NP_112265.1  4-aminobutyrate aminotransferase, mitochondrial

      See identical proteins and their annotated locations for NP_112265.1

      Status: PROVISIONAL

      Source sequence(s)
      D87839
      UniProtKB/TrEMBL
      A0A8I6G7C5
      Related
      ENSRNOP00000003633.2, ENSRNOT00000003633.6
      Conserved Domains (2) summary
      TIGR00699
      Location:34496
      GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
      COG0160
      Location:42498
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      7503351..7599474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245760.5XP_006245822.1  4-aminobutyrate aminotransferase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006245822.1

      UniProtKB/Swiss-Prot
      O70539, P50554, Q66HM1
      UniProtKB/TrEMBL
      A0A8I6G7C5, A6K4M1
      Conserved Domains (2) summary
      TIGR00699
      Location:34496
      GABAtrns_euk; 4-aminobutyrate aminotransferase, eukaryotic type
      COG0160
      Location:42498
      GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]
    2. XM_063269943.1XP_063126013.1  4-aminobutyrate aminotransferase, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      O70539, P50554, Q66HM1
      UniProtKB/TrEMBL
      A0A8I6G7C5, A6K4M1
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